Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
Kai-Di Chen, Kui-Ling Wang, Chen Chen, Yi-Jia Zhu, Wen-Wen Tang, Yu-Ji Wang, Ze-Peng Chen, Lin-Hai He, Yu-Gen Chen, Wei Zhang · World journal of gastroenterology · 2024
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In Sprague-Dawley rats, compared with the Lop group, the abundance of Firmicutes (86.70% vs 91.77%) increased whereas that of Bacteroidetes (7.50% vs 5.26%) and Actinobacteria (3.03% vs 0.81%) decreased in the HRW group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in Sprague-Dawley rats. Compared with the Lop group, the abundance of Firmicutes (86.70% vs 91.77%) increased whereas that of Bacteroidetes (7.50% vs 5.26%) and Actinobacteria (3.03% vs 0.81%) decreased in the HRW group.
What the Researchers Studied
The researchers studied Sprague-Dawley rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 3.0 mg/L H₂. Compared with the Lop group, the abundance of Firmicutes (86.70% vs 91.77%) increased whereas that of Bacteroidetes (7.50% vs 5.26%) and Actinobacteria (3.03% vs 0.81%) decreased in the HRW group. The authors concluded that HRW attenuates constipation-associated intestinal oxidative stress via SIRT1/Nrf2/HO-1 signaling pathway, modulating gut microbiota and serum metabolites. β-Leu and traumatic acid are potential metabolites that upregulate SIRT1 expression and reduce oxidative stress. To determine whether hydrogen-rich water (HRW) alleviates constipation and its potential mechanism. Figure 5 Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was Sprague-Dawley rats. The reported sample size was 18. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 3.0 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.