Shop Hydrogen Products
Hydrogen Research Study
← Back to Research Library
Preclinical animal evidenceAnimal studyhydrogen-rich water

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats.

Yukako Muramatsu, Mikako Ito, Takahiro Oshima, Seiji Kojima, Kinji Ohno · Pediatric pulmonology · 2016

View Original Study

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Hydrogen Water Research
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method hydrogen-rich water

H2HUBB TAKEAWAY

In rats, at P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

What the Findings Mean

H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in rats. At P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes.

What the Researchers Studied

The researchers studied rats. The study used a preclinical animal experiment.

What Effects Did Molecular Hydrogen Have?

Reported treatment duration: 24 hr. At P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. Inflammatory marker proteins of TNFα and IL-6 were increased by LPS treatment, and hydrogen suppressed them. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress.

Why These Findings Matter

These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

How Strong Is This Evidence?

This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.

Technical Study Details

H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The reported treatment duration was 24 hr.

Limitations and Safety

No separate limitations or safety findings were identified in the source text available to H2HUBB.

Original Study and H2HUBB Research Context

H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.

CONTINUE EXPLORING

Related Molecular Hydrogen Studies

Editorial NoticePreclinical animal evidenceAnimal studyhydrogen-rich water

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.

Ying Lin, Akinori Kashio, Takashi Sakamoto, Keigo Suzukawa, Akinobu Kakigi, Tatsuya Yamasoba · Neuroscience letters · 2011

In guinea pigs, the ABR thresholds at 2 and 4 kHz were significantly better on post-noise days 1, 3, and 14 in hydrogen-treated animals when compared to the normal water-treated controls. These preclinical findings…

Primary topic
Hydrogen Water Research
Delivery method
hydrogen-rich water
Study ID
DOI: 10.1016/j.neulet.2010.09.064
View Study View Source
Preclinical animal evidenceAnimal studyhydrogen-rich water

Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil.

Hideo Ogawa, Masahiro Okada, Masachika Shudou, Kiyofumi Gyo, Naohito Hato · Neuroscience letters · 2018

In an animal model, when the animals were treated with hydrogen-rich water, cochlear damage was significantly reduced: the increase in ABR threshold was 11.7±2.6dB at 8kHz and the IHC loss was 7.5%±2.1% at the…

Primary topic
Hydrogen Water Research
Delivery method
hydrogen-rich water
Main limitation
The abstract alone may not report all methodological limitations; full-text review is required.
Study ID
DOI: 10.1016/j.neulet.2017.12.013
View Study View Source
Preclinical animal evidenceAnimal studyOther or not reported

The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice.

Yang-Suk Yoon, Dong-Heui Kim, Soo-Ki Kim, Soon-Bong Song, Young Uh, Dan Jin, Xu-Feng Qi, Yung-Chien Teng, Kyu-Jae Lee · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2011

The researchers found that the rate of body weight gain was significantly more increased in MTF+ERW group than MTF+PW group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…

Primary topic
Hydrogen Water Research
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1016/j.fct.2011.04.033
View Study View Source