Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling.
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-Ichi Hirano, Li-Ping Ye, Xiao-Kang Li · American journal of physiology. Gastrointestinal and liver physiology · 2021
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, HRW improved hepatic steatosis in the CSAA + HRW group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Primary hepatocytes were cultured in a closed vessel filled with 21% O₂ + 5% CO₂ + 3.8% H₂ and N₂ as the base gas to verify the response of primary hepatocytes in a high concentration of hydrogen gas in vitro.
What the Researchers Found
HRW improved hepatic steatosis in the CSAA + HRW group.
H₂ Mechanisms / Biological Findings
The purpose of the authors' experiment was to investigate the protective effect of drinking water with a high concentration of hydrogen, namely, hydrogen-rich water (HRW), on mice with nonalcoholic fatty liver disease to elucidate the mechanism underlying the therapeutic action of molecular hydrogen. Sirtuin 1 (Sirt1) induction by molecular hydrogen via the HO-1/adenosine monophosphate activated protein kinase (AMPK)/peroxisome proliferator-activated receptor α (PPARα)/peroxisome proliferator-activated receptor γ (PPAR-γ) pathway suppresses palmitate-mediated abnormal fat metabolism. Molecular hydrogen inhibits LPS-induced inflammation via an HO-1/interleukin 10 (IL-10)-independent pathway.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.