The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa.
Xiaohong Chen, Yanjian Chen, Xingchui Lin, Qian Ye, Sheng Zhang, Yunpeng Wang, Meizhu Chen, Weiming Yan · Heliyon · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
However, no significant difference in mean IOP was observed before and after HRW consumption (t = 1.115, P = 0.276) ( Table 2 ). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
Short-term HRW drinking slightly improved visual function in patients with primary RP, whereas no significant improvement was found in the thickness of the retina and choroid. However, no significant difference in mean IOP was observed before and after HRW consumption (t = 1.115, P = 0.276) ( Table 2 ).
What the Researchers Studied
The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 1.6 mg/L H₂; Source-reported hydrogen exposure: 500 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. Short-term HRW drinking slightly improved visual function in patients with primary RP, whereas no significant improvement was found in the thickness of the retina and choroid. However, no significant difference in mean IOP was observed before and after HRW consumption (t = 1.115, P = 0.276) ( Table 2 ).
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The reported sample size was 2. The study used a human clinical study. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 1.6 mg/L H₂.
Limitations and Safety
Reported limitations: Due to the limitation of obtaining human retinal sections, the researchers employed OCT to assess the effect of HRW drinking on retinal and choroidal morphology in RP patients in the present study. The analysis of the results might be affected by the relatively small sample size, individual differences among patients, and the short follow-up time of observation.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.