Hydrogen rich water in oral pathology: an update.
Thorakkal Shamim · Medical gas research · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, hydrogen-rich water used for prevention or treatment of oxidative stress-related diseases in oral cavity 3: The study was conducted to investigate protective effects of hydrogen-rich water against reactive oxygen species induced cellular harmful events and cell death in human gingival fibroblasts and three-dimensional gingival tissue equivalents. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. Hydrogen-rich water used for prevention or treatment of oxidative stress-related diseases in oral cavity 3: The study was conducted to investigate protective effects of hydrogen-rich water against reactive oxygen species induced cellular harmful events and cell death in human gingival fibroblasts and three-dimensional gingival tissue equivalents.
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
The study was an in vitro scratch assay, which showed hydrogen-rich water achieved cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or three-dimensional tissue equivalents and wound-healing promotion, superadded with reactive oxygen species scavenging and relief from glutathione diminishment. Hydrogen-rich water used for prevention or treatment of oxidative stress-related diseases in oral cavity 3: The study was conducted to investigate protective effects of hydrogen-rich water against reactive oxygen species induced cellular harmful events and cell death in human gingival fibroblasts and three-dimensional gingival tissue equivalents. The authors concluded that i would like to suggest certain updates to the above review article regarding hydrogen rich water in oral pathology with emphasis on recent studies done in 2017. 2, 3 Hydrogen-rich water suppresses gingival oxidative stress and alveolar bone resorption in oral cavity 2. The study was conducted in 344 male Fischer rats divided into three groups of six rats each with a control group fed om regular diet and drinking distilled water and two experimental groups fed a high-fat diet and drinking distilled water or hydrogen-rich water. used for prevention or treatment of oxidative stress-related diseases in oral cavity 3.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 344. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://europepmc.org/article/PMC/PMC5937302.