Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial.
Minju Sim, Chong-Su Kim, Woo-Jeong Shon, Young-Kwan Lee, Eun Young Choi, Dong-Mi Shin · Scientific reports · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1, the changes from baseline to the 4th week in serum biological antioxidant potential (BAP), derivatives of reactive oxygen, and 8-Oxo-2'-deoxyguanosine did not differ between groups; however, in those aged ≥ 30 y, BAP increased greater in the HW group than the PW group. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1. The changes from baseline to the 4th week in serum biological antioxidant potential (BAP), derivatives of reactive oxygen, and 8-Oxo-2'-deoxyguanosine did not differ between groups; however, in those aged ≥ 30 y, BAP increased greater in the HW group than the PW group.
What the Researchers Studied
The researchers studied In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 0.753 ± 0.012 mg/L H₂; Source-reported hydrogen exposure: 500 mL hydrogen-rich water per serving, 3 servings/day; approximately 0.38 mg H₂ per reported serving; H2HUBB calculated daily H₂ dose: approximately 1.13 mg H₂/day, calculated from the source-reported dissolved H₂ concentration and total hydrogen-water volume consumed per day; reported treatment duration: 4 weeks. The changes from baseline to the 4th week in serum biological antioxidant potential (BAP), derivatives of reactive oxygen, and 8-Oxo-2'-deoxyguanosine did not differ between groups; however, in those aged ≥ 30 y, BAP increased greater in the HW group than the PW group. The authors concluded that these finding suggest HW increases antioxidant capacity thereby reducing inflammatory responses in healthy adults.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1. The reported sample size was 158. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 0.753 ± 0.012 mg/L H₂. The source-reported hydrogen exposure was 500 mL hydrogen-rich water per serving, 3 servings/day; approximately 0.38 mg H₂ per reported serving. H2HUBB calculated daily H₂ dose: approximately 1.13 mg H₂/day, calculated from the source-reported dissolved H₂ concentration and total hydrogen-water volume consumed per day. This is a deterministic dose translation, not a separately measured value. The reported treatment duration was 4 weeks.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.