Hydrogen water versus normal saline for post-surgical irrigation: A study on healing and complication rates after third molar extraction.
Harshini Devi, Indra Kumar S P, Narendar Ramesh, Arrvinthan S U, Asok Kumar R S, Sarmatha Selvaraj · Bioinformation · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 30 patients, showed all patients improved over time and that patients in the hydrogen water group had significantly greater improvements in pain, swelling and trismus, as well as a lower incidence of dry socket from postoperative day 2 onward. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 30 patients. Showed all patients improved over time and that patients in the hydrogen water group had significantly greater improvements in pain, swelling and trismus, as well as a lower incidence of dry socket from postoperative day 2 onward.
What the Researchers Studied
The researchers studied 30 patients. The study used a human clinical study. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 0–100 mM H₂ (≈0–201.6 mg/L). Showed all patients improved over time and that patients in the hydrogen water group had significantly greater improvements in pain, swelling and trismus, as well as a lower incidence of dry socket from postoperative day 2 onward. The authors concluded that hydrogen water irrigation reduces postoperative pain, swelling, trismus, dry socket and infection to a great extent compared to normal size. These findings suggest that hydrogen water possesses enhanced anti-inflammatory and antibacterial effects, contributing to superior healing outcomes compared to normal saline.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 30 patients. The reported sample size was 30. The study used a human clinical study. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 0–100 mM H₂ (≈0–201.6 mg/L).
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.