Mechanisms of antioxidative and anti-inflammatory… : Tungs’ Medical Journal
2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. The search strategy included combinations of keywords such as “chronic kidney disease,” “oxidative stress,” “inflammation,” “antioxidant therapy,” “molecular hydrogen,” “H₂ therapy,” and “renal protection.” Articles were screened for relevance based on their titles and abstracts, and those addressing mechanistic insights, preclinical findings, and clinical studies were prioritized. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. The search strategy included combinations of keywords such as “chronic kidney disease,” “oxidative stress,” “inflammation,” “antioxidant therapy,” “molecular hydrogen,” “H₂ therapy,” and “renal protection.” Articles were screened for relevance based on their titles and abstracts, and those addressing mechanistic insights, preclinical findings, and clinical studies were prioritized.
What the Researchers Studied
The authors reviewed mechanisms of antioxidative and anti-inflammatory…: Tungs' Medical Journal.
What Effects Did Molecular Hydrogen Have?
Increased endoplasmic reticulum (ER) stress: increases in patients with CKD undergoing hemodialysis, and this imbalance influences redox signaling mediators, modulating ROS levels. [ ] This mechanism will be comprehensively discussed in the “Mechanisms of Molecular H₂ Therapy in Oxidative Stress and Inflammation” section below. The search strategy included combinations of keywords such as “chronic kidney disease,” “oxidative stress,” “inflammation,” “antioxidant therapy,” “molecular hydrogen,” “H₂ therapy,” and “renal protection.” Articles were screened for relevance based on their titles and abstracts, and those addressing mechanistic insights, preclinical findings, and clinical studies were prioritized.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.ovid.com/jnls/tmj/fulltext/10.4103/etmj.etmj-d-25-00005~mechanisms-of-antioxidative-and-anti-inflammatory-treatments.