Molecular Hydrogen and Its Effect on Wound Healing and Tissue Regeneration
Mikhail Yu. Artamonov, Tyler W. LeBaron, Felix A. Pyatakovich, Inessa A. Minenko · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Further research should optimize delivery, dose, timing, and tissue bioavailability to translate promising preclinical findings into effective clinical hydrogen treatments for wound care. molecular hydrogen wound healing oxidative stress antioxidant therapy inflammation hydrogen gas hydrogen water topical delivery medical gases Author Information Show + Mikhail Yu. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Arly preclinical evidence shows hydrogen therapy may promote wound healing through accelerated closure, decreased inflammation, and mitigated tissue injury.
What the Researchers Studied
The authors reviewed molecular Hydrogen and Its Effect on Wound Healing and Tissue Regeneration.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 5% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 5% source-reported H₂ gas concentration. Arly preclinical evidence shows hydrogen therapy may promote wound healing through accelerated closure, decreased inflammation, and mitigated tissue injury. Consumption of hydrogen water reduced levels of TNF-α, IL-6, IL-1β, chemokine (C-C motif) ligand 2, and other inflammation markers in multiple rodent models through inhibition of pathways like NF-kB and JNK [ 26 ]. In one study, drinking hydrogen-rich water improved grafted skin viability and reduced oxidative stress in five patients undergoing surgical reconstruction for head and neck tumors [ 28 ].
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The reported sample size was 5. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 5% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.intechopen.com/chapters/1177362.