Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
Johanna Viana, Cecilia Castro, Víctor Leiva · Medical gas research · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. H₂ consistently demonstrated protective effects against apoptosis, fibrosis, inflammation, and oxidative stress across acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease models. By addressing the current limitations, harmonizing protocols, and deepening the evidence on safety and efficacy, H₂ therapy may evolve into a well-established treatment option in renal medicine. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. H₂ consistently demonstrated protective effects against apoptosis, fibrosis, inflammation, and oxidative stress across acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease models.
What the Researchers Studied
The authors reviewed molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
What Effects Did Molecular Hydrogen Have?
A comprehensive approach was applied to identify, screen, and select relevant studies on H₂ therapies for kidney-related conditions. INCLUSION AND EXCLUSION CRITERIA: the researchers included primary experimental and clinical studies explicitly addressing H₂-based therapies in kidney-related conditions. H₂ consistently demonstrated protective effects against apoptosis, fibrosis, inflammation, and oxidative stress across acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease models. The authors concluded that hydrogen therapy holds promise for renoprotection in both acute kidney injury and chronic kidney disease. For instance, “oxidative stress” (degree = 0.96) is near-ubiquitous, underlining its pivotal role in H₂-based renal interventions, whereas “hydrogen” (0.68) and “inflammation” (0.68) also exhibit high connectivity, bridging multiple research subdomains.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
Reported limitations: By addressing the current limitations, harmonizing protocols, and deepening the evidence on safety and efficacy, H₂ therapy may evolve into a well-established treatment option in renal medicine.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.