Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.
Akito Shimouchi, Kazutoshi Nose, Tomoe Mizukami, Dock-Chil Che, Mikiyasu Shirai · Advances in experimental medicine and biology · 2013
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
As a result, was found to be approximately 0.7 μmol/min/m(2)BSA, which was compatible with the findings the researchers obtained using H₂-rich water. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. As a result, [Formula: see text] was found to be approximately 0.7 μmol/min/m(2)BSA, which was compatible with the findings the researchers obtained using H₂-rich water. [Formula: see text] varied markedly when pretreatment fasting to reduce colonic fermentation was not employed, i.e., when the subject's baseline breath hydrogen level was 10 ppm or greater.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 10 mg/L H₂; Source-reported hydrogen exposure: 10 mg/L H₂. As a result, [Formula: see text] was found to be approximately 0.7 μmol/min/m(2)BSA, which was compatible with the findings the researchers obtained using H₂-rich water. [Formula: see text] varied markedly when pretreatment fasting to reduce colonic fermentation was not employed, i.e., when the subject's baseline breath hydrogen level was 10 ppm or greater. Inhaling or ingesting hydrogen (H₂) gas improves oxidative stress-induced damage in animal models and humans.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 10 mg/L H₂. The source-reported hydrogen exposure was 10 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.