Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.
Wan-Jun Zhu, Masaaki Nakayama, Takefumi Mori, Keisuke Nakayama, Junichiro Katoh, Yaeko Murata, Toshinobu Sato, Shigeru Kabayama, Sadayoshi Ito · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011
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Independent study record
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H2HUBB TAKEAWAY
Intake of water with high levels of dissolved hydrogen (H₂) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The researchers studied the biological effects of water with dissolved H(2) on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD).
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
In the rats given FW, unilateral kidney I/R induced significant increases in plasma monocyte chemoattractant protein-1, methylglyoxal and blood urea nitrogen. Histologically, significant increases were found in glomerular adhesion, cardiac fibrosis, number of ED-1 (CD68)-positive cells and nitrotyrosine staining in the contralateral kidney and the heart.
H₂ Mechanisms / Biological Findings
Hydrogen (H(2)) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals.
Authors’ Conclusion
The authors concluded that consumption of EW by ad libitum drinking has the potential to ameliorate ischemia-induced cardio-renal injury in CKD model rats. This indicates a novel strategy of applying H(2) produced by water electrolysis technology for the prevention of CKD cardio-renal syndrome.