Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.
Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, Gang Wu · Medicine · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. However, it tends to remove more normal bone, resulting in bone loss and postoperative sensitivity. [ 107 ] As for ultrasonic scaling, limited by cleaning angle and size of the ultrasonic instrument, bacteria and virulence factors cannot be completely removed in special anatomical parts of the subgingival root surface. The inflammatory reaction is prone to recurrence. [ 108 ] Other problems such as additional loss of root surface and spray pollution also exist. [ 109 ] Molecular hydrogen, the therapeutic antioxidant, has favorable physicochemical properties. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years.
What the Researchers Studied
The authors reviewed molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.
What Effects Did Molecular Hydrogen Have?
Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The reported sample size was 20. The study used a narrative review. The hydrogen delivery method was multiple hydrogen delivery methods (hydrogen-rich water, saline infusion).
Limitations and Safety
Reported limitations: However, it tends to remove more normal bone, resulting in bone loss and postoperative sensitivity. [ 107 ] As for ultrasonic scaling, limited by cleaning angle and size of the ultrasonic instrument, bacteria and virulence factors cannot be completely removed in special anatomical parts of the subgingival root surface. The inflammatory reaction is prone to recurrence. [ 108 ] Other problems such as additional loss of root surface and spray pollution also exist. [ 109 ] Molecular hydrogen, the therapeutic antioxidant, has favorable physicochemical properties.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.