Mitochondria: one of the vital hubs for molecular hydrogen’s biological functions.
Xiaoyue Zhang, Fei Xie, Shiwen Ma, Chen Ma, Xue Jiang, Yang Yi, Yifei Song, Mengyu Liu, Pengxiang Zhao, Xuemei Ma · Frontiers in cell and developmental biology · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined this review aims to 1) summarize the experimental evidence on the impact of H₂ on mitochondrial function; 2) provide an overview of the mitochondrial pathways underlying the biological effects of H₂, and 3) discuss H₂ metabolism in eukaryotic organisms and its relationship with mitochondria.
Main Findings Across the Literature
Although several possible mechanisms have been proposed, they cannot fully explain the extensive biological effects of H₂. Based on previous findings, this review proposes that H₂ may regulate mitochondrial quality control through diverse pathways in response to varying degrees of mitochondrial damage.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.