Molecular hydrogen (H 2) has been reported to be effective for a variety of disorders and its effect has been ascribed to a selective scavenge of hydroxyl radicals (•OH) at the beginning. Consumption of H 2 was either by
Mami Noda1*, Kyota Fujita1, Ikuroh · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, this study showed that administration of H₂-rich saline by peritoneal injection (6 mL/kg/24 h) improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats. Consequently, increase in the concentration of H₂ in the brain was not detected [13]. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. This study showed that administration of H₂-rich saline by peritoneal injection (6 mL/kg/24 h) improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 3% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 3% source-reported H₂ gas concentration; reported treatment duration: 90 min. This study showed that administration of H₂-rich saline by peritoneal injection (6 mL/kg/24 h) improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats. The authors concluded that pre-treated rats were sacrificed 48 hr after toxin injection, and the tyrosine hydroxylase (TH) activity at the striatum was decreased in both H₂ and control groups, which indicated that H₂ did not directly detoxicate 6-OHDA, but exerted a delayed protective effect for dopaminergic cells. Hydrogen Works as a Signal Modulator Reduction of oxidative stress has been confirmed in various oxidative stress-related disease models. Ohta S (2012) Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 3% source-reported H₂ gas concentration. The reported treatment duration was 90 min.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.hilarispublisher.com/open-access/multiple-effects-of-molecular-hydrogen-and-its-distinct-mechanism-2329-6895-2-189.pdf.