Neuroprotective Effects of Molecular Hydrogen: A Critical Review.
Wei Chen, Han-Ting Zhang, Shu-Cun Qin · Neuroscience bulletin · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined neuroprotective Effects of Molecular Hydrogen: A Critical Review.
Main Findings Across the Literature
Molecular hydrogen (H₂) is a physiologically inert gas. More specifically, H₂ has protective effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfusion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain, neurodegenerative diseases, cognitive dysfunction induced by surgery and anesthesia, anxiety, and depression. Further, H₂ is easy to use and has neuroprotective effects with no major side-effects, indicating that H₂ administration is a potential therapeutic strategy in clinical settings.
Authors’ Conclusion
The authors concluded that meanwhile, the researchers review the effectiveness and safety of H₂ in the treatment of various nervous system diseases based on preclinical and clinical studies, leading to the conclusion that H₂ can be a simple and effective clinical therapy for CNS diseases such as ischemia-reperfusion brain injury, Parkinson's disease, and diseases characterized by cognitive dysfunction.