Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice.
Akio Matsumoto, Megumi Yamafuji, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruaki Nakaya · Scientific reports · 2013
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Independent study record
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H2HUBB TAKEAWAY
In mice, verified the expression of β 1 – and β 2 – adrenergic receptors in stomach tissue samples by real-time PCR method, and determined that there were no significant changes in the levels of expression after administration of oral H₂ -water for 4 days (data not shown). However, ingestion of lactulose had no significant effect on dopaminergic neuron survival in 6-OHDA-induced PD model rats (although alveolar H₂ concentrations were elevated) 19. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in mice. verified the expression of β 1 – and β 2 – adrenergic receptors in stomach tissue samples by real-time PCR method, and determined that there were no significant changes in the levels of expression after administration of oral H₂ -water for 4 days (data not shown).
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 7 days. verified the expression of β 1 – and β 2 – adrenergic receptors in stomach tissue samples by real-time PCR method, and determined that there were no significant changes in the levels of expression after administration of oral H₂ -water for 4 days (data not shown). The authors concluded that the findings demonstrate that the neuroprotective effects of oral hydrogen water, which produces negligible levels of H₂ in the brain, result from gastric induction of the neuroprotective peptide hormone ghrelin and the subsequent activation of ghrelin receptors. The increase in plasma ghrelin levels by oral hydrogen water was eliminated by administration of the β 1 -adrenergic receptor-specific blocker, atenolol (10 mg/kg i.p.) injected 30 min prior to H₂ water administration on each of four days ( Figure 3 ). Thus, activation of β 1 -adrenergic receptors is required for hydrogen water-induced enhancement of circulating ghrelin.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The reported treatment duration was 7 days.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.