Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.
Tingting Wang, Ling Zhao, Mengyu Liu, Fei Xie, Xuemei Ma, Pengxiang Zhao, Yunqi Liu, Jiala Li, Minglian Wang, Zhaona Yang, Yutong Zhang · Toxicology and applied pharmacology · 2014
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Independent study record
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H2HUBB TAKEAWAY
In An in vitro study demonstrated that AChE activity was more intense in HRW than in normal water with or without chlorpyrifos-oxon (CPO), the metabolically-activated form of CPF, immunostaining results showed that the increased glial fibrillary acidic protein (GFAP) expression in astrocytes induced by CPF exposure can be ameliorated by HRW intake. The authors concluded that these observations suggest that HRW intake can protect rats from CPF-induced neurotoxicity, and the protective effects of hydrogen may be mediated by regulating the oxidant and antioxidant status of rats. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
An in vitro study demonstrated that AChE activity was more intense in HRW than in normal water with or without chlorpyrifos-oxon (CPO), the metabolically-activated form of CPF.
How Molecular Hydrogen Was Used
Hydrogen-rich water
What Molecular Hydrogen Changed
Immunostaining results showed that the increased glial fibrillary acidic protein (GFAP) expression in astrocytes induced by CPF exposure can be ameliorated by HRW intake.
Proposed Mechanism
These observations suggest that HRW intake can protect rats from CPF-induced neurotoxicity, and the protective effects of hydrogen may be mediated by regulating the oxidant and antioxidant status of rats. Furthermore, this work defines a novel mechanism of biological activity of hydrogen by directly increasing the AChE activity.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.