Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice.
Ignacio Martínez-Martel, Sylmara Esther Negrini-Ferrari, Olga Pol · Antioxidants (Basel, Switzerland) · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, this study proved that prophylactic treatment with DULO combined with HRW prevented the mechanical allodynia and muscle strength deficits caused by CIS in mice of both sexes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. This study proved that prophylactic treatment with DULO combined with HRW prevented the mechanical allodynia and muscle strength deficits caused by CIS in mice of both sexes.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 0.15 mM H₂ (≈0.302 mg/L); Source-reported hydrogen exposure: 10 mL hydrogen-rich water per reported dose; approximately 0 mg H₂ per reported serving. This study proved that prophylactic treatment with DULO combined with HRW prevented the mechanical allodynia and muscle strength deficits caused by CIS in mice of both sexes. Other authors have also reported that molecular hydrogen exhibits its anti-inflammatory and antioxidative properties through inhibiting the JNK pathway [ 64 ].
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The reported sample size was 6. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 0.15 mM H₂ (≈0.302 mg/L). The source-reported hydrogen exposure was 10 mL hydrogen-rich water per reported dose; approximately 0 mg H₂ per reported serving.
Limitations and Safety
Reported limitations: A limitation of this study is the absence of changes induced by CIS and/or the treatments (DULO and HRW, both individually and in combination) in the expression of the majority of proteins analyzed in the AMG, which did not permit the elucidation of the primary mechanisms underlying the efficacy of these treatments in mitigating. This study proved that prophylactic treatment with DULO combined with HRW prevented the mechanical allodynia and muscle strength deficits caused by CIS in mice of both sexes.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.