Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
Keliang Xie, Yonghao Yu, Yuping Pei, Lichao Hou, Shaoyang Chen, Lize Xiong, Guolin Wang · Shock (Augusta, Ga.) · 2010
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. The researchers found that the beneficial effects of H₂ treatment on sepsis and sepsis-associated organ damage were associated with the decreased levels of oxidative product, increased activities of antioxidant enzymes, and reduced levels of high-mobility group box 1 in serum and tissue. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
Main Findings Across the Literature
In the present study, the researchers found that H₂ inhalation starting at 1 and 6 h after cecal ligation and puncture (CLP) or sham operation significantly improved the survival rate of septic mice with moderate or severe CLP in a concentration- and time-dependent manner. Moderate or severe CLP mice showed significant multiple organ damage characterized by the increases of lung myeloperoxidase activity, wet-to-dry weight ratio, protein concentration in bronchoalveolar lavage, serum biochemical parameters, and organ histopathologic scores at 24 h after CLP operation, which was significantly attenuated by 2% H₂ treatment.
Authors’ Conclusion
The authors concluded that recently, it has been suggested that molecular hydrogen (H₂) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, the most cytotoxic reactive oxygen species) and effectively protects against organ damage induced by I/R.