Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration.
Tao Chen, Ye Tao, Weiming Yan, Guoqing Yang, Xuemin Chen, Ruidan Cao, Lei Zhang, Junhui Xue, Zuoming Zhang · Experimental eye research · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, compared to MNU-treated rats, retinal malondialdehyde (MDA) content in MNU + hydrogen-rich saline rats significantly decreased while superoxide dismutase (SOD) activity significantly increased. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as in the present study, the researchers explored the therapeutic effects of hydrogen-rich saline a selective ros scavenger, on mnu-induced photoreceptor degeneration.
What the Researchers Found
Intraperitoneal (IP) administration of hydrogen-rich saline ameliorated MNU-induced photoreceptor degeneration in terms of morphology and function: Sharply decreased thickness of the retinal outer nuclear layer (ONL) and flattened photopic and scotopic electroretinogram (ERG) waveforms, typically seen in response to MNU treatment, were substantially rescued in rats cotreated with MNU and hydrogen-rich saline (MNU + hydrogen-rich saline). Compared to MNU-treated rats, retinal malondialdehyde (MDA) content in MNU + hydrogen-rich saline rats significantly decreased while superoxide dismutase (SOD) activity significantly increased. However, this enhanced protection of structure and function in the peripheral retina is unlikely the result of site-dependent variation in the efficacy of hydrogen-rich saline; rather, it is most likely due to reduced susceptibility of peripheral photoreceptors to MNU-induced degeneration.
H₂ Mechanisms / Biological Findings
In the present study, the researchers explored the therapeutic effects of hydrogen-rich saline a selective ROS scavenger, on MNU-induced photoreceptor degeneration.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.