Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.
Akinori Kashio, Chikako Yamada, Kazuo Yasuhara, Teru Kamogashira, Shinichi Someya, Tatsuya Yamasoba · Hearing research · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. The threshold shifts in animals given GeO 2 and hydrogen water showed approximately 20–30 threshold shifts at all frequencies, which were significantly different from those in animals given GeO 2 +normal water only at 32 kHz ( p <0.05). The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. The threshold shifts in animals given GeO 2 and hydrogen water showed approximately 20–30 threshold shifts at all frequencies, which were significantly different from those in animals given GeO 2 +normal water only at 32 kHz ( p <0.05).
What the Researchers Studied
The authors reviewed taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 3 months. The threshold shifts in animals given GeO 2 and hydrogen water showed approximately 20–30 threshold shifts at all frequencies, which were significantly different from those in animals given GeO 2 +normal water only at 32 kHz ( p <0.05). The authors concluded that these results suggest that daily supplements or consumption of antioxidants, such as taurine, coenzyme Q10, and hydrogen-rich water, may be a promising intervention to slow SNHL associated with mitochondrial dysfunction. In the current study, the researchers observed that antioxidants, such as taurine, CoQ10, and hydrogen water, attenuated GeO 2 -induced SNHL and degeneration of the stria vascularis and SGCs, which implies that ROS play a key role in GeO 2 -mediated damage in the cochlea. Another reason may be the unique mechanism of scavenging system of hydrogen, which selectively scavenges free hydroxyl radicals (•OH) ( Sato et al., 2008; Ohsawa et al., 2007 ).
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water. The reported treatment duration was 3 months.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.