The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial.
Menekşe Nazlı Aker, İlknur M Gönenç, Dilan Çalişici, Menekşe Bulut, Duried Alwazeer, Tyler W LeBaron · BMC women's health · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In Participants were randomized into two groups (intervention group=33, control group=32) using the block randomization method, mizuno et al. (2017) also reported that four weeks of HRW application in adult volunteers improved mood, reduced anxiety, enhanced autonomic nervous system function, and strengthened quality of life [ 38 ]. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in Participants were randomized into two groups (intervention group=33, control group=32) using the block randomization method. Mizuno et al. (2017) also reported that four weeks of HRW application in adult volunteers improved mood, reduced anxiety, enhanced autonomic nervous system function, and strengthened quality of life [ 38 ].
What the Researchers Studied
The researchers studied Participants were randomized into two groups (intervention group=33, control group=32) using the block randomization method. The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 2 L hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂; reported treatment duration: 5 minutes. Mizuno et al. (2017) also reported that four weeks of HRW application in adult volunteers improved mood, reduced anxiety, enhanced autonomic nervous system function, and strengthened quality of life [ 38 ]. Hydrogen-rich water (HRW) has antioxidant and anti-inflammatory properties that may treat PMS.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was Participants were randomized into two groups (intervention group=33, control group=32) using the block randomization method. The reported sample size was 775. The study used a randomized, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 2 L hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. The reported treatment duration was 5 minutes.
Limitations and Safety
Reported limitations: Limitations: Participants could not be followed for over two menstrual cycles after completing the intervention.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.