The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials.
Honghui Ye, Jinyong Fang, Mohammad Safargar, Hadi Fareed, Kousalya Prabahar, Pei Jin · Diabetology & metabolic syndrome · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 2025 participants with placebo or standard water in adults with mean body mass index (BMI) ≥ 25 kg/m2, HRW significantly reduced total cholesterol (TC) (WMD: − 6.71 mg/dL; 95% CI: − 10.38 to − 3.04; P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 3.21 mg/dL; 95% CI: − 6.31 to − 0.10; P = 0.043). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 2025 participants with placebo or standard water in adults with mean body mass index (BMI) ≥ 25 kg/m2. HRW significantly reduced total cholesterol (TC) (WMD: − 6.71 mg/dL; 95% CI: − 10.38 to − 3.04; P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 3.21 mg/dL; 95% CI: − 6.31 to − 0.10; P = 0.043).
What the Researchers Studied
The researchers studied 2025 participants with placebo or standard water in adults with mean body mass index (BMI) ≥ 25 kg/m2. The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
HRW significantly reduced total cholesterol (TC) (WMD: − 6.71 mg/dL; 95% CI: − 10.38 to − 3.04; P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: − 3.21 mg/dL; 95% CI: − 6.31 to − 0.10; P = 0.043). The authors concluded that HRW supplementation in overweight or obese adults produces small, statistically detectable but clinically modest reductions in TC and LDL-C, with minimal effects on TG and HDL-C. Hydrogen-rich water (HRW) has been proposed as a potential adjunctive intervention due to its antioxidant and anti-inflammatory properties.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 2025 participants with placebo or standard water in adults with mean body mass index (BMI) ≥ 25 kg/m2. The reported sample size was 757. The study used a randomized, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.