The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial.
Nikola Todorovic, Sonja Baltic, David Nedeljkovic, Jovan Kuzmanovic, Darinka Korovljev, Dejan Javorac, Katarina Bijelic, Nebojsa Kladar, Alex Tarnava, Sergej M Ostojic · Medicina (Kaunas, Lithuania) · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The results demonstrated that hydrogen-rich water significantly mitigated cravings (p = 0.05), improved subjective sleep quality (p = 0.05), reduced total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and increased plasma glucagon-like peptide-1 levels (p = 0.05) compared to the control. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 36 participants. The results demonstrated that hydrogen-rich water significantly mitigated cravings (p = 0.05), improved subjective sleep quality (p = 0.05), reduced total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and increased plasma glucagon-like peptide-1 levels (p = 0.05) compared to the control.
What the Researchers Studied
The researchers studied 36 participants. The study used a randomized human clinical trial. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
1 L hydrogen-rich water per reported dose; dissolved H₂ concentration was not reported in the available source text, so H2HUBB did not estimate milligrams of H₂. The results demonstrated that hydrogen-rich water significantly mitigated cravings (p = 0.05), improved subjective sleep quality (p = 0.05), reduced total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and increased plasma glucagon-like peptide-1 levels (p = 0.05) compared to the control. The authors concluded that hydrogen-rich water may serve as a safe and effective dietary strategy to address appetite regulation and related metabolic indices in individuals with obesity. And Objectives: Preliminary studies indicate that dihydrogen (H₂) may affect molecular pathways involved in appetite regulation; however, its role in influencing patient-reported appetite outcomes in individuals with obesity remains uncertain.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 36 participants. The reported sample size was 36. The study used a randomized human clinical trial. The hydrogen delivery method was hydrogen-rich water. H2HUBB translates the reported hydrogen dose as 1 L hydrogen-rich water per reported dose; dissolved H₂ concentration was not reported in the available source text, so H2HUBB did not estimate milligrams of H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.