The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury.
Quan Hu, Yingxiao Li, Zhaochen Lin, Hao Zhang, Haoyue Chen, Cui Chao, Chuanliang Zhao · Drug design, development and therapy · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI). The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. 39 Dohi et al reported that treatment with hydrogen-rich culture medium for 24 hours significantly enhanced mitochondrial basal respiration, reserve respiration, and nonmitochondrial respiration while increasing ATP production.
What the Researchers Studied
The authors reviewed the Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 24 hours. 39 Dohi et al reported that treatment with hydrogen-rich culture medium for 24 hours significantly enhanced mitochondrial basal respiration, reserve respiration, and nonmitochondrial respiration while increasing ATP production. The authors concluded that in the last twenty years (especially in recent years), substantial progress has been made in basic and preclinical studies (including studies on the use of hydrogen for treating SCI) and clinical therapeutic studies. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI, with an aim to better explore the medical value of hydrogen and provide new avenues for the adjuvant treatment of SCI.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The reported treatment duration was 24 hours.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.