The Rieske iron-sulfur protein is a primary target of molecular hydrogen.
Shuto Negishi, Mikako Ito, Tomoya Hasegawa, Hikaru Otake, Bisei Ohkawara, Akio Masuda, Hiroyuki Mino, Tyler W LeBaron, Kinji Ohno · Redox biology · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration.
How Molecular Hydrogen Was Used
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. Given the evolutionary link with hydrogenases, the researchers examined RISP as a potential target of H₂.
What Molecular Hydrogen Changed
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration.
Proposed Mechanism
The mechanisms underlying the biomedical effects of molecular hydrogen (H₂) remain poorly understood and are often attributed to its selective reduction of hydroxyl radicals, based on the long-held notion that H₂ is biologically inert.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.