The Rieske iron-sulfur protein is a primary target of molecular hydrogen.
Shuto Negishi, Mikako Ito, Tomoya Hasegawa, Hikaru Otake, Bisei Ohkawara, Akio Masuda, Hiroyuki Mino, Tyler W LeBaron, Kinji Ohno · Redox biology · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration.
What the Researchers Studied
The researchers studied The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. Given the evolutionary link with hydrogenases, the researchers examined RISP as a potential target of H₂. The mechanisms underlying the biomedical effects of molecular hydrogen (H₂) remain poorly understood and are often attributed to its selective reduction of hydroxyl radicals, based on the long-held notion that H₂ is biologically inert.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was The researchers observed that H₂ induces the mitochondrial unfolded protein response (UPRmt) in cultured cells exposed to H₂ and in mouse liver after H₂ water administration. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.