Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease.

This uncontrolled human study examined Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease. The abstract describes Human participants. The abstract reports: Laser Doppler perfusion imaging demonstrated that H2‑saturated water improved perfusion recovery, decreased the rate of necrosis, increased the capillary density in the gastrocnemius muscle…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis

This uncontrolled human study examined Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Furthermore, it has been found that molecular hydrogen alleviate fibrosis by eliminating intracellular ROS and inhibiting the activation of the PTEN/AKT/mTOR pathway. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway.

This animal study examined Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: This study confirmed that HRS promotes diabetic wound healing by alleviating oxidative stress and inflammation, and these effects may be mechanistically associated with the…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.

This animal study examined Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: In this study, we found that hydrogen improved cardiac dysfunction and abnormal morphological structure in streptozotocin-induced diabetic mice. This is an automated editorial draft based on the abstract and requires source review before publication.

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The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats.

This animal study examined The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 30 days. The abstract reports: HW has antioxidant activity in STZ-induced DM rats, increasing insulin, IRs, and SOD. This is an automated editorial draft based on the abstract and requires source review before publication.

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The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.

This uncontrolled human study examined The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: The results showed that drinking HW suppressed the increase in glucose, total cholesterol, oxidative stress, and inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats.

This animal study examined Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.

This study protocol examined Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. The abstract describes Planned or registered research population; hydrogen delivered as hydrogen water; reported duration 10 minutes. This is an automated editorial draft based on the abstract and requires source review before publication.

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Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes.

This animal study examined Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen; reported duration 4 weeks. The abstract reports: Subcutaneous injection of H significantly improves type 2 diabetes mellitus and diabetic nephropathy-related outcomes in a mouse model, supporting further consideration of subcutaneous injection…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.

This randomized controlled trial examined Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. The abstract describes Human participants; sample size 30; hydrogen delivered as hydrogen water; reported duration 8 weeks. The abstract reports: In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle.

This animal study examined Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. The abstract describes Mouse model. The abstract reports: The results show that H(2) promoted 2-[(14)C]-deoxy-d-glucose (2-DG) uptake into C2C12 cells via the translocation of glucose transporter Glut4 through activation of phosphatidylinositol-3-OH kinase…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.

This in vitro or cellular study examined Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. The abstract describes Fibroblast model. The abstract reports: The results revealed that both mannitol and high glucose could cause oxidative stress in HSFs. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model.

This animal study examined Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 4 weeks. The abstract reports: Our preliminary studies indicated that H(2) saline may have potentials in the clinical treatment of diabetic retinopathy. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.

This animal study examined Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: These findings may contribute to clarifying the mechanism of action of H therapy in sepsis. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents.

This in vitro or cellular study examined Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. The abstract describes HaCaT keratinocyte model. The abstract reports: Nanoparticle tracking analysis showed that fresh HW contains 1.17 × 10/mL of nano-sized hydrogen bubbles. This is an automated editorial draft based on the abstract and requires source review before publication.

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