Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels.
This animal study examined Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Our results suggest that HS attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota
This animal study examined Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen; reported duration 7 months. The abstract reports: The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.
This in vitro or cellular study examined Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water. The abstract reports: Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.
This animal study examined Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis.
This animal study examined Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis. The abstract describes Zebrafish model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe role of hydrogen therapy in Alzheimer’s disease management: Insights into mechanisms, administration routes, and future challenges.
This narrative review examined The role of hydrogen therapy in Alzheimer’s disease management: Insights into mechanisms, administration routes, and future challenges. The abstract describes Published literature review. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study.
This uncontrolled human study examined Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study. The abstract describes Human participants; reported duration 6 months. The abstract reports: To objectively assess the neuron integrity, diffusion tensor imaging (DTI) with advanced magnetic resonance imaging (MRI) was applied to neuron bundles passing through the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial.
This randomized controlled trial examined The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. The abstract describes Human participants; hydrogen delivered as hydrogen water and topical hydrogen; reported duration 6 month. The abstract reports: A significant treatment vs. time interaction was found for telomere length (P = 0.049), with the length increased after HRW intervention (from 0.99 ± 0.15 at baseline to…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases.
This narrative review examined Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases. The abstract describes Published literature review. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress
This in vitro or cellular study examined Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. The abstract describes Keratinocyte model. The abstract reports: In the present study, HO dose-dependently impaired the adenosine triphosphate (ATP)-induced Ca response, which was partially protected via co-treatment with β-mercaptoethanol, resulting in reduced…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice.
This animal study examined Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice. The abstract describes Mouse model. The abstract reports: H can prevent oxidative stress in D-galactose-induced aging mice when administered by different routes. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
This in vitro or cellular study examined Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence. The abstract describes Cell culture / in vitro model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.
This animal study examined Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Thus, this study showed the antioxidant and anti-senescence effects of hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
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