Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia.
This animal study examined Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Gasometric results (pH, pO and pCO levels) were better in the CDH + HW group than in the CDH group. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Therapy and Its Future Prospects for Ameliorating COVID-19: Clinical Applications, Efficacy, and Modality.
Molecular hydrogen is renowned as an odorless and colorless gas. The recommendations developed by China suggest that the inhalation of hydrogen molecules is currently advised in COVID-19 pneumonia treatment. The therapeutic effects of molecular hydrogens have been confirmed after numerous clinical trials and animal-model-based experiments, which have expounded that the low molecular weight of hydrogen enables it to easily diffuse and permeate through the cell membranes to produce a variety of biological impacts.
Read MoreMolecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.
This animal study examined Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism. The abstract describes Mouse model. The abstract reports: The expression of might be regulated indirectly through sequential regulation by H, 4-hydroxy-2-nonenal, and Akt/FoxO1 signaling, as suggested in cultured cell experiments. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates neuronal ischemia–reperfusion injury by protecting mitochondrial function in rats.
This animal study examined Hydrogen-rich saline attenuates neuronal ischemia–reperfusion injury by protecting mitochondrial function in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia-reperfusion (I/R) injury of multiple organs. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice.
This animal study examined Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen-rich saline. The abstract reports: Previous studies have demonstrated that hydrogen-rich saline (HS) protects against bile duct ligation (BDL)-induced liver injury by suppressing oxidative stress and inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial
This randomized controlled trial examined Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. The abstract describes Human participants; sample size 34; reported duration 10 weeks. The abstract reports: H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects. The present findings highlight the potential role of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.
This animal study examined Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. The abstract describes Mouse model. The abstract reports: We found that H activated the expression of sets of genes regulated by histone H3K27 methylation status. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.
This animal study examined Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results collectively indicated that hydrogen significantly attenuated CUMS-induced depressive-like behavior and monoamine neurotransmitter deficiency, as well as protected the brain from oxidative stress…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice.
This animal study examined Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice. The abstract describes Mouse model. The abstract reports: Although the underlying mechanisms of bmTBI are largely unknown, some studies suggested that bmTBI is associated with blood-brain barrier disruption, oxidative stress, and edema…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside.
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated that H may act as an antioxidant to exert therapeutic and preventive effects on various disorders, including metabolic diseases.
Read MoreMolecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens.
This animal study examined Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: We found that HRS administration was able to inhibit the acquisition and transfer of 0.1 and 0.5 mg/kg METH-induced behavioral sensitization to a certain extent,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich water on depressive-like behavior in mice.
This uncontrolled human study examined Effects of hydrogen-rich water on depressive-like behavior in mice. The abstract describes Human participants; hydrogen delivered as hydrogen water and hydrogen-rich saline. The abstract reports: Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway.
This animal study examined Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The result showed that HS administration alleviated HI-induced edema, infract volume and cellular apoptosis within the cortex of neonatal mice. Accompanying these indices of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats
This animal study examined Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine.
This animal study examined Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. The abstract describes Porcine model; sample size 14; reported duration 20 min. The abstract reports: H2 gas attenuates markedly ischemia and portal hyperperfusion injury in pigs with massive hepatotectomy, possibly by the reduction of inflammation and oxidative stress, maybe…. This is an automated editorial draft based on the abstract and requires source review before publication.
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