Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.
This animal study examined Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that intake of HRW had no significant effect on the activities of various cytochrome P450 (CYP) enzymes (CYP1A1, 1A2, 2B, 2C,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions.
This animal study examined Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions. The abstract describes Rat model. The abstract reports: The mechanism of this phenomenon suggests that H2 may have effectively attenuated AOC‑induced inflammatory and oxidative damage, and decreased matrix metalloproteinase activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
This animal study examined Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation. The abstract describes Rat model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: Storage of liver grafts in hydrogen-rich UW solution resulted in superior functional and morphologic protection against IRI via the up-regulation of HO-1 expression. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.
This animal study examined Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. The abstract describes Mouse model. The abstract reports: Therefore, the results of this study show that ERW can be proposed to protect the liver against CCl(4)-induced oxidative damage in mice, and the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.
This animal study examined Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water; reported duration 8 weeks. The abstract reports: Consumption of hydrogen-rich water may be an effective treatment for NASH by reducing hepatic oxidative stress, apoptosis, inflammation, and hepatocarcinogenesis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection.
This animal study examined Inhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation; reported duration 120 minutes. The abstract reports: In this experimental study, we showed that inhaled hydrogen during major liver resection unquestionably reduced the level of oxidative stress associated with ischemia-reperfusion damage.…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
This animal study examined Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. The abstract describes Rat model. The abstract reports: We found that H2 ameliorated H/R-induced cholangiocytes apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
This uncontrolled human study examined Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: HRW significantly attenuates oxidative stress in CHB patients, but further study with long-term treatment is required to confirm the effect of HRW on liver…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAnti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
This animal study examined Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. The abstract describes Mouse model. The abstract reports: It has been suggested therefore to use gaseous hydrogen in a new anti-inflammatory strategy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAnti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice.
This animal study examined Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: HRW protects against chronic EtOH-induced liver injury, possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLong-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice.
This animal study examined Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: This study reveals that long-term hydrogen-rich water (HRW) consumption provides significant hepatoprotection in mice under chronic stress. HRW normalizes liver enzyme levels, enhances antioxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLong-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury.
This animal study examined Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 8 months. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease.
This animal study examined A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: In the present study, we found that HRCC treatment improved methionine-and-choline-deficient diet (MCD)-induced hepatic steatosis, increased aspartate aminotransferase and alanine aminotransferase levels, and elevated…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells.
This in vitro or cellular study examined Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water. The abstract reports: Some clinical evidence suggests that H may alleviate fatty liver disease, but the precise molecular mechanisms, particularly the regulation of lipid droplet (LD) metabolism,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota.
This animal study examined Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota. The abstract describes Mouse model. The abstract reports: Hydrogen gas (H) has been demonstrated to be an efficient antioxidant in various diseases in animals as well as humans. This is an automated editorial draft based on the abstract and requires source review before publication.
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