Molecular hydrogen is a promising therapeutic agent for pulmonary disease.
Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants.
Read MoreMolecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis
This animal study examined Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis. The abstract describes Mouse model. The abstract reports: These data demonstrated that H is efficient in suppressing allergen-induced asthma and could be developed as a therapeutics for asthma and other conditions of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe use of ultrapure molecular hydrogen enriched with atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus COVID-19.
This uncontrolled human study examined The use of ultrapure molecular hydrogen enriched with atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus COVID-19. The abstract describes Human participants; hydrogen delivered as oxyhydrogen. The abstract reports: Many studies have been carried out that have demonstrated that hydrogen has strong anti-inflammatory properties. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.
This animal study examined Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: LPS-stimulated THP-1 and HUVEC-C cells and showed that hydrogen decreases TF expression and MMP-9 activity, which were abolished by the Trx1 inhibitor, PX12. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury.
This animal study examined The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results suggest that hydrogen inhalation inhibits the deterioration of respiratory physiological function and alveolar fibrosis in this model of lung injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of molecular hydrogen on lung injury from lung transplantation
This narrative review examined Protective effects of molecular hydrogen on lung injury from lung transplantation. The abstract describes Published literature review; hydrogen delivered as hydrogen water and hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The reviewed studies showed that H improved the outcomes of lung transplantation by decreasing oxidative stress and inflammation at the donor and recipient phases. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.
This observational study examined Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. The abstract describes Human participants; sample size 10; hydrogen delivered as hydrogen inhalation; reported duration 45 min. The abstract reports: A single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen is a potential protective agent in the management of acute lung injury.
Acute lung injury (ALI) and acute respiratory distress syndrome, which is a more severe form of ALI, are life-threatening clinical syndromes observed in critically ill patients. Treatment methods to alleviate the pathogenesis of ALI have improved to a great extent at present. Although the efficacy of these therapies is limited, their relevance has increased remarkably with the ongoing pandemic caused by the novel coronavirus disease 2019 (COVID-19), which causes severe respiratory distress syndrome.
Read MoreHydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
This uncontrolled human study examined Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses.
This animal study examined Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses. The abstract describes Mouse model. The abstract reports: We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSaturated hydrogen saline protects rats from acute lung injury induced by paraquat.
This animal study examined Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Saturated hydrogen saline is effective in preventing acute lung injury caused by PQ. Possibly, it can neutralize toxic oxygen radicals selectively and alleviate the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats.
BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats. METHODS: Rats were treated with OA (0.1 mL/kg) to induce ALI and then administered with HSS (5 mL/kg) by intravenous (iv) and intraperitoneal (ip) injection, respectively. Three hours after the injection with OA, the arterial oxygen partial pressure (PaO), arterial oxygen saturation (SaO), carbon dioxide partial pressure (PaCO), and bicarbonate (HCO) levels were analyzed using blood gas analyzer.
Read MoreSaturated hydrogen saline ameliorates lipopolysaccharide-induced acute lung injury by reducing excessive autophagy.
The pathogenesis of acute lung injury (ALI) induced by lipopolysaccharide (LPS) involves excessive pulmonary inflammation and oxidative stress. In turn, autophagy is associated with inflammatory diseases and organ dysfunction, and studies have demonstrated that LPS treatment may trigger autophagy. Thus, excessive autophagy may stimulate the strong inflammatory response observed in the development of LPS-induced ALI.
Read MoreProtection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging
This animal study examined Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results suggest the potential utility of these SPECT biomarkers for in vivo assessment of key cellular pathways in the pathogenesis of ALI and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis.
This uncontrolled human study examined Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. The abstract reports: RESULTS Mice exhibited increases in collagen deposition, hydroxyproline, type I collagen contents, and TGF-β1 production in lung tissues after LPS treatment. This is an automated editorial draft based on the abstract and requires source review before publication.
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