Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
This in vitro or cellular study examined Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?. The abstract describes Cell culture / in vitro model. The abstract reports: Recent studies in animal models of focal or global cerebral ischemia and cerebral ischemia in humans suggest that hydrogen has pleiotropic neuroprotective properties. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models.
This animal study examined Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models. The abstract describes Mouse model; reported duration 60 days. The abstract reports: These results suggest that H therapy can mitigate toxic metabolites in the astrocytic urea cycle, thereby reducing neurodegeneration and memory loss in AD. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels.
This animal study examined Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Our results suggest that HS attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota
This animal study examined Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen; reported duration 7 months. The abstract reports: The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis.
This animal study examined Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis. The abstract describes Zebrafish model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study.
This uncontrolled human study examined Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study. The abstract describes Human participants; reported duration 6 months. The abstract reports: To objectively assess the neuron integrity, diffusion tensor imaging (DTI) with advanced magnetic resonance imaging (MRI) was applied to neuron bundles passing through the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress
This in vitro or cellular study examined Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. The abstract describes Keratinocyte model. The abstract reports: In the present study, HO dose-dependently impaired the adenosine triphosphate (ATP)-induced Ca response, which was partially protected via co-treatment with β-mercaptoethanol, resulting in reduced…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice.
This animal study examined Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice. The abstract describes Mouse model. The abstract reports: H can prevent oxidative stress in D-galactose-induced aging mice when administered by different routes. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
This in vitro or cellular study examined Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence. The abstract describes Cell culture / in vitro model. This is an automated editorial draft based on the abstract and requires source review before publication.
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