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443 Articles

Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

By Aug 8, 2026 0 Comments

In SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. The authors linked these findings to activation of the PINK1/Parkin pathway. These preclinical findings add evidence supporting molecular…

Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats.

By H2HUBB Aug 7, 2026 0 Comments

The researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis…

Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.

By H2HUBB Aug 7, 2026 0 Comments

In male Sprague-Dawley rats, sTZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of…

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

By H2HUBB Aug 5, 2026 0 Comments

The researchers observed a significant increase in the concentration of H₂ in the placenta after the oral administration of hydrogen-saturated water to the mothers, with less placental oxidative…

Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas.

By H2HUBB Aug 5, 2026 0 Comments

In mice, hydrogen gas concentrations in maternal livers and whole fetuses in EFA-FOS were significantly higher than those in CONT and EFA, respectively (P <.05). These preclinical findings…

Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.

By H2HUBB Aug 5, 2026 0 Comments

In rats, exercise increased cleaved caspase-3 expression, and H₂ reduced this response. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.

By H2HUBB Aug 5, 2026 0 Comments

In mice, intermittent hypoxia significantly increased plasma levels of low- and very low-density cholesterol and the amount of 4-hydroxy-2-nonenal-modified protein adducts in the LV myocardium. These preclinical findings…

Molecular hydrogen (H 2) has been reported to be effective for a variety of disorders and its effect has been ascribed to a selective scavenge of hydroxyl radicals (•OH) at the beginning. Consumption of H 2 was either by

By H2HUBB Jul 28, 2026 0 Comments

In mice, hydrogen Works as a Signal Modulator Reduction of oxidative stress has been confirmed in various oxidative stress-related disease models. These preclinical findings add evidence supporting molecular…

Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

By H2HUBB Jul 28, 2026 0 Comments

Propose that the cardiovascular benefits of alpha-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H(2) in the gastrointestinal tract. This…

Randomized, double‐blind, multicenter trial of hydrogen water for Parkinson’s disease

By H2HUBB Jul 28, 2026 0 Comments

Randomized, double‐blind, multicenter trial of hydrogen water for Parkinson's disease A previous randomized, doubleblind study showed that drinking 1,000 mL of H₂ water per day for 48 weeks…

Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats.

By H2HUBB Jul 28, 2026 0 Comments

In female Sprague-Dawley rats, saturated hydrogen saline could protect the retina from light-induced damage by attenuating oxidative stress. These results are preclinical and suggest molecular hydrogen's therapeutic potential…

Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model.

By H2HUBB Jul 28, 2026 0 Comments

In rats, maximum intracavernous pressure in diabetic rats decreased significantly compared to controls and increased significantly compared to untreated diabetic rats after hydrogen-rich saline treatment. These results are…

Molecular Hydrogen and Its Effect on Wound Healing and Tissue Regeneration

By H2HUBB Jul 28, 2026 0 Comments

This narrative review examined the available molecular-hydrogen literature. Further research should optimize delivery, dose, timing, and tissue bioavailability to translate promising preclinical findings into effective clinical hydrogen treatments…

Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.

By H2HUBB Jul 28, 2026 0 Comments

In a laboratory model, a recent study demonstrated that hydrogen gas with a good permeability in biological membranes can treat various disorders by exerting its selective anti-oxidation and…

Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.

By H2HUBB Jul 28, 2026 0 Comments

In mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These results are preclinical and suggest molecular hydrogen's therapeutic potential in…