Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans.
This uncontrolled human study examined Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. The abstract describes Human participants. The abstract reports: We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy
This uncontrolled human study examined Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy. The abstract describes Human participants. The abstract reports: This case suggests that molecular hydrogen therapy may be a helpful adjunct treatment for SDH with midline shift. Conventional therapies, including craniectomy, hyperbaric oxygen,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury.
This animal study examined Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers.
The main aim of this randomized-controlled cross-over interventional trial was to assess the acute effects of taking a single dose of hydrogen-rich water (HRW), and compare it with caffeine, HRW plus caffeine, and control water, for alertness, brain metabolism, brain and oxygen saturation, and self-reported adverse events in healthy men and women who were habitual coffee drinkers and were sleep-deprived for 24 hr. Sixteen apparently healthy young adults (8 men and 8 women; age 24.0 ± 3.5 years) were allocated in a cross-over design to receive a single-dose drink of HRW (8 ppm), caffeine (50 mg),…
Read MoreMolecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders
Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen's antioxidative and anti-inflammatory effects have aroused widespread interest. Due to its excellent antioxidant and anti-inflammatory properties, hydrogen therapy via different routes of administration exhibits great therapeutic potential for a wide range of brain disorders, including Alzheimer's disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic…
Read MoreHydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats.
This animal study examined Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats. The abstract describes Rat model. The abstract reports: These findings suggest that H augments cellular antioxidant defense capacity through activation of MAPK signaling pathways, leading to HO-1 expression and subsequent upregulation of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
This animal study examined Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results showed that hypoxia–ischemia injury induced the inflammatory response of microglia; however, these changes were inhibited by hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
This animal study examined Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: It has previously been demonstrated that hyperglycemia‑induced oxidative stress and inflammation are closely associated with the development of diabetic complications, including diabetic neuropathy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
This uncontrolled human study examined Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: These data demonstrated that HRS can improve survival rate, attenuate neuroinflammation, astrocyte and microglial activation, neuronal injury and mitochondrial dysfunction in juvenile SAE rat…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreNeuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.
This animal study examined Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: These results suggested that H2 holds promise for the prevention of inflammation related to perinatal brain injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.
This animal study examined PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression. The abstract describes Mouse model. The abstract reports: The results showed the expression of PPARα was decreased in SAE mice and that activation of PPARα in septic mice improved the survival rate…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreImpact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
This animal study examined Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMaternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.
This animal study examined Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Our results suggest that LPS-induced apoptosis, oxidative damage and inflammation in the fetal brain were ameliorated by maternal H2 administration. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.
This uncontrolled human study examined Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 40 min. The abstract reports: This observation demonstrated that hydrogen-rich saline peritoneal injection improves histologic and functional assessment in a rat model of CO encephalopathy. Hydrogen saline has potentials…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.
This uncontrolled human study examined Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. The abstract describes Human participants. The abstract reports: HG was found to induce severe oxidative stress and promote the caspase‑dependent and caspase‑independent apoptosis of SCs. This is an automated editorial draft based on the abstract and requires source review before publication.
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