Protective Effect of Hydrogen on Sodium Iodate-Induced Age-Related Macular Degeneration in Mice.
In mice, mechanistically, HRW greatly reduced the oxidative stress reaction through decreased MDA levels, increased SOD production, and decreased ROS content. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreRandomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen.
The researchers found that administering a persistent H₂-generating supplement increased the human exhaled H₂ concentration (p < 0.01) and improved tear stability (p < 0.01) and dry eye symptoms (p < 0.05) significantly. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreProtective effect of saturated hydrogen saline against blue light-induced retinal damage in rats.
In female Sprague-Dawley rats, saturated hydrogen saline could protect the retina from light-induced damage by attenuating oxidative stress. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen saline prevents selenite-induced cataract in rats.
In rats, compared with Group B, the mean activities of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase, levels of GSH, and total sulfhydryl contents were higher, whereas the level of malondialdehyde was lower following treatment with hydrogen saline. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreDesign of a Functional Eye Dressing for Treatment of the Vitreous Floater.
This study evaluated a functional eye dressing designed to deliver both molecular hydrogen and oxygen around the eye. In uncontrolled clinical observations involving 28 patients, the authors reported improvement in sensory-floater symptoms. Because the dressing delivered two gases and the study did not include a controlled comparator, the contribution of molecular hydrogen cannot be isolated.
Read MoreHydrogen saline prevents selenite-induced cataract in rats.
In rats, hydrogen saline prevents selenite-induced cataract in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals.
In 118 participants with mild-to-moderate dry eye symptoms, a significant decline in fTBUT was observed in the placebo group (p = 0.04), but not the H₂-producing group (p = 0.26). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
Read MoreNovel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?
This narrative review examined the available molecular-hydrogen literature. Accumulating evidence suggest that H₂ is protective against multiple ophthalmic diseases, including cataracts, dry eye disease, diabetic retinopathy (DR) and other fields. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreThe potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.
This narrative review examined the available molecular-hydrogen literature. It is the authors' hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich the authors' pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen inhalation therapy for inflammation and eye diseases: a review of the literature.
Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature is classified as Narrative review using Review or synthesis. The primary model is Published literature review. Detailed outcomes require source review because an abstract was not accessible.
Read MoreHydrogen-rich Saline is ineffective in oxygen-induced retinopathy.
In mice, kEY FINDING: The leakage and non-perfusion areas of retinal blood vessels were not alleviated in the HRS treatment group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential for retinopathy and the biological pathways measured in this model.
Read MoreThe reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline.
In rats, hRS preserved the retinal function and mitigated the reduction of photoreceptor degeneration in MNU-treated retinas. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration.
In rats, compared to MNU-treated rats, retinal malondialdehyde (MDA) content in MNU + hydrogen-rich saline rats significantly decreased while superoxide dismutase (SOD) activity significantly increased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Research progress of hydrogen-rich saline for eye diseases].
This narrative review examined the research progress of hydrogen-rich water for eye diseases in the domestic and foreign literatures. (Chin J Ophthalmol, 2018, 54: 631-635). At present, there are few studies on the treatment of eye diseases with hydrogen-rich water. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[The protection of hydrogen-rich saline on a rat dry eye model induced by scopolamine hydrobromide].
In female Wistar rats, hRS eyedrops group and HRS intraperitoneal injection group can relieve the signs of dry eye, improve the pathological damage of cornea and conjunctiva, and protect the ocular surface of a rat dry eye model, which is better than NS groups from the 14(th) day. (Chin J Ophthalmol, 2017, 53: 363-372). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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