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In 20 patients with LAHNC, although the H₂ -treated group exhibited a numerically smaller reduction in serum uric acid levels than the CCRT-alone group, the between-group difference was not statistically significant ( p = 0.11; Table 6 ). Consistent with these findings,…
Read ArticleIn For human ex vivo studies, the researchers collected blood samples from six healthy humans and added normal saline or hydrogen-rich saline to blood and platelet-rich plasma, collagen-induced…
Read ArticleIn rats, through transmission electron microscopy, the researchers observed that the GSDMD membrane pores in AMs were increased at 12 and 24 h post-burn compared with sham rats;…
Read ArticleThe researchers found that H₂-O₂ mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac…
Read ArticleIn The characterization, toxicity, and pH-responsive H₂ release of AB@HPDA was detected in vitro, hPDA and AB@HPDA significantly inhibited IDD, as tested by X-ray, MRI, disc water content,…
Read ArticleIn guinea pigs, the ABR thresholds measured immediately after the simultaneous exposure to noise and carbon monoxide significantly increased at all frequencies in group 1 while in group…
Read ArticleIn an animal model, undamaged neuron numbers were significantly higher in the HI-H₂ group than in the HI group (p < 0.01), although RT-aEEG was not different. These…
Read ArticleIn SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. The authors linked these…
Read ArticleIn male Wistar rats, during reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). These preclinical findings add evidence supporting…
Read ArticleIn rats, another limitation to the study is related to the lack of measurement of hydrogen concentration in the arterial blood, which may affect the hypotheses regarding the…
Read ArticleIn mice, intermittent hypoxia significantly increased plasma levels of low- and very low-density cholesterol and the amount of 4-hydroxy-2-nonenal-modified protein adducts in the LV myocardium. These preclinical findings…
Read ArticleIn The sphere-forming ability of glioma cells was suppressed by hydrogen treatment, the sphere-forming ability of glioma cells was suppressed by hydrogen treatment. The authors concluded that experimental…
Read ArticleIn male Wistar rats, during mild SI, H₂ reduced plasma surges of proinflammatory cytokines (TNF-α and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented…
Read ArticleIn a laboratory model, the protective effect of hydrogen (H(2)) on ROS-induced diseases has been proved by many researches, which demonstrated that through eliminating •OH and •ONOO-, H(2)…
Read ArticleIn male Sprague-Dawley rats, immunofluorescence indicated the expression of glutamate transporter-1 in the spinal ischemia group was significantly decreased compared with the sham group, which was attenuated by…
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