Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice.
In mice, mHW intake improved cardiac hypertrophy, shortened the width of cardiomyocytes, dilated the capillaries and arterioles, activated myocardial eNOS-Ser-1177 phosphorylation, and restored left ventricular function in DIO mice. MHW intake for 2 weeks did not improve blood sugar or body weight but decreased heart weight in DIO mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreConstitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
In C57BL/6 mice, although the increase in superoxide anion production did not significantly differ between the hydrogen and control groups, DNA damage was decreased as a result of reduction of reactive oxygen species such as hydroxyl radical (⋅OH) and peroxynitrite (ONOO-) in the hydrogen group. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreA New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
This narrative review examined the available molecular-hydrogen literature. Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich water. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreH2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells.
H(2) is a therapeutic antioxidant that can reduce oxidative stress. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MorePost-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study.
In rats, nFkB-p65 and c-Fos in the nucleus were unexpectedly unchanged by IRI regardless of H₂ treatment, indicating the absence of inflammation in this model. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period.
In Pulmonary microvascular endothelial cells were divided into 4 groups: blank, control, oxygen (O₂), and H₂, the pathological changes in the cell and mitochondria were alleviated after H₂ administration. The authors concluded that hydrogen-attenuated inflammatory response in a PMVECs lung transplantation model during cold storage. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreTreatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
In mice, although treatment of diabetic mice with hydrogen water did not significantly affect blood glucose level, it significantly attenuated cardiac hypertrophy and reduced expression of atrial natriuretic factor and β-myosin heavy chain. It alleviated cardiac fibrosis and reduced expression of collagen I and III, transforming growth factor beta, alpha-smooth muscle actin, and osteopontin; it reduced cardiac caspase-3 activity and ratio of bax/bcl-2. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreInsufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model.
In an animal model, although the W/D ratio in the CPB group significantly increased as compared with that in the SHAM group, such an increase was also suppressed significantly in the CPB + H₂ group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreAnti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion.
In rats, it also decreased neutrophil infiltration, 3-nitrotyrosine level, expression of intercellular adhesion molecule 1(ICAM-1) and myeloperoxidase (MPO) activity in the area at risk zones (AAR) of rat hearts subjected to regional myocardial I/R, and attenuated the increase of I/R induced proinflammatory cytokine tumor necrosis factor-α (TNF-a) and interleukin-1β (IL-1b) levels in the AAR. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
It was shown that MNU could inhibit the proliferation and specific physiological functions of CECs by increasing apoptosis and decreasing the expression of ZO-1 and Na+/K+-ATPase, whereas H₂ improved the proliferation and physiological function of CECs by anti-apoptosis. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreMolecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.
The researchers found that both 0.3 mmol/L and 0.6 mmol/L (i.e., saturated) H₂-rich media improved cell viability and cellular apoptosis in LPS-activated HUVECs and that 0.6mmol/L (i.e., saturated) H₂-rich medium exerted an optimal effect. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death.
In a laboratory model, the OC in the hydrogen group was higher than in the control group, but the difference was not statistically significant (P = 0.0862). The authors concluded that hydrogen gas inhalation during EVLP improved the function of DCD lungs, which may increase the utilization of DCD lungs. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats.
In Sprague Dawley rats, hRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cellular apoptosis and the release of MDA and LDH compared with the CPB group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-γ, hydrogen treatment was also associated with increased graft ATP levels and increased activity of the enzymes in mitochondrial respiratory chain. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreAdministration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.
In mice, the numbers of endothelial cells in the atheroma expressing the senescence factors p16INK4a and p21 decreased in HFD-fed mice given HW compared with HFD-fed mice given control water. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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