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959 Articles

Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation.

By H2HUBB Jul 22, 2026 0 Comments

In rats, the LPS challenge reduced the expression of genes related to FAO, including perioxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), perioxisome proliferator-activated receptor alpha (PPARα), Estrogen-related receptor alpha (ERRα), and their downstream targets, in mRNA and protein level, which were attenuated…

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Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway.

By H2HUBB Jul 22, 2026 0 Comments

In JAK2 knockdown experiments using siRNA, HRS treatment following hypoxia/reoxygenation also significantly increased the viability of myocardial cells, decreased the rate of myocardial cellular apoptosis, elevated the levels…

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Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition.

By H2HUBB Jul 22, 2026 0 Comments

In mice, significant lung injury at 24 h post-TBI got significantly reduced by treatment of 2% H₂. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…

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Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats – A possible new hydrogen resource for clinical use.

By H2HUBB Jul 22, 2026 0 Comments

This publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.

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Inhalation of 2% Hydrogen Improves Survival Rate and Attenuates Shedding of Vascular Endothelial Glycocalyx in Rats with Heat Stroke.

By H2HUBB Jul 22, 2026 0 Comments

In Wistar rats, serum levels of endotoxin, syndecan-1, malondialdehyde, and tumor necrosis factor-α decreased, whereas superoxide dismutase levels increased, indicating that inhalation of 2% hydrogen attenuated the damage…

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Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model.

By H2HUBB Jul 22, 2026 0 Comments

In rats, hydrogen saline significantly reduced the infarct volume and edema and improved the neurological function, when it was administered at 0, 3 and 6 h after reperfusion.…

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Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage rats: a pilot study.

By H2HUBB Jul 22, 2026 0 Comments

In contrast, hydrogen gas may have increased survival of animals that would have died without treatment, thus biasing the neurobehavior scores of the SAH + hydrogen group toward…

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Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway.

By H2HUBB Jul 22, 2026 0 Comments

In rats, hydrogen gas reduced brain swelling, improved neurological function, and lowered markers of oxidative stress and neuronal pyroptosis after subarachnoid hemorrhage. These preclinical findings add evidence supporting…

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H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.

By H2HUBB Jul 22, 2026 0 Comments

In rats, serum IL-6 levels 2 hours after ROSC were not significantly increased in post-CA rats of the H₂ group (848.9±257.0 pg/mL) or H₂ +TH group (933.3±339.0 pg/mL)…

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Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.

By H2HUBB Jul 22, 2026 0 Comments

In mice, compared with female mice, H₂ administration post-ICH exhibited fewer neuroprotective effects, including decreased sucrose consumption and time spent sniffing a novel mouse, increased immobility time, downregulated…

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Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis.

By H2HUBB Jul 22, 2026 0 Comments

In the H₂ treatment group (group H), these proteins were significantly decreased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…

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Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats.

By H2HUBB Jul 22, 2026 0 Comments

In an animal model, the inhalation of 42% H₂ for one hour per day for 48 h significantly reduced brain edema, decreased the extravasation of sodium fluorescein, and…

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Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis.

By H2HUBB Jul 22, 2026 0 Comments

In mice, hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…

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Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury.

By H2HUBB Jul 22, 2026 0 Comments

In rats, at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content,…

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Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.

By H2HUBB Jul 22, 2026 0 Comments

In 5 patients, lPO slightly increased at 3 h after the initiation of H₂ gas inhalation but was then maintained over 24 h. These findings add human evidence…

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