Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway.
In Sprague-Dawley rats, mitochondrial ATP content, mitochondrial complex I, and mitochondrial complex III activity were significantly decreased in the MI group, which was improved after hydrogen administration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases.
This narrative review examined the available molecular-hydrogen literature. This article highlights the dual role of diet in generating molecular hydrogen ( H₂ ) in the gut, and H₂ 's subsequent influence on the pathophysiology and prevention of CVD and T2DM. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.
This narrative review examined the available molecular-hydrogen literature. In this review, evidence of the potential benefits of hydrogen molecules obtained from in vitro, in vivo, and clinical investigations are comprehensively summarized and discussed with a focus on the cardiovascular aspects. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMolecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury 1.
This narrative review examined the available molecular-hydrogen literature. Irradiation of the rats caused a significant increase in lipid peroxidation, which was mitigated by pre-treatment of the animals with molecular hydrogen. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreChronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats.
In rats, treatment with HRS had no significant effect on blood pressure, but it significantly improved baroreflex function in SHR. Although treatment with HRS had no significant effect on nitric oxide amount in circulating or aorta, it suppressed endothelial nitric oxide synthase expression and upregulated dimethylarginine dimethylaminohydrolase 2 expression in SHR. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen Gas in Cancer Treatment.
This narrative review examined the available molecular-hydrogen literature. Growing evidence has shown that hydrogen gas can either alleviate the side effects caused by conventional chemotherapeutics, or suppress the growth of cancer cells and xenograft tumor, suggesting its broad potent application in clinical therapy. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreEngineering a Tumor‐Targeted MgH 2 @Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation
In vivo, it achieves efficient tumor homing, suppresses tumor growth in both immunodeficient and immunocompetent models, and reprograms the TME by lowering Tregs and M2 macrophages while enhancing M1 polarization and CD3 + /CD45 + T cell infiltration. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreMolecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.
This narrative review examined the available molecular-hydrogen literature. Recently, there has been an increasing number of papers on the efficacy of H₂ against cancer and its effects in mitigating the side effects of cancer treatment. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor.
In a laboratory model, ammonia borane was linked to the surface of polydopamine through the interaction of hydrogen bonding, which could destroy redox homoeostasis in tumor cells and reduce inflammation by H₂ release in tumor microenvironment. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer.
In This study aimed to investigate the role of H₂ incombination with 5-fluorouracil (5-FU) in cancer treatment both in vitro and in vivo using the colon 26 cell line, hydrogen water administration improved the survival of mice with colon 26-induced cancer. The authors concluded that, high-content hydrogen water can inhibit colon cancer, particularly in combination with 5-fluorouracil. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMolecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice.
In male HR-1 hairless mice, H₂ preserved the GSH/GSSG ratio following acute UVB exposure and reduced nuclear Nrf2 accumulation during chronic exposure. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study.
In participants with radiotherapy or concurrent chemo-radiotherapy, qoL improved in the HW group (p = 0.03), while OFC scores showed no significant difference between groups (p = 0.74). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model.
In Balb/c mice, administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content and fibrosis as compared to the CRC control group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of perioperative hydrogen inhalation on brain edema and prognosis in patients with glioma: a single-center, randomized controlled study.
In Participants in hydrogen (H) group that inhaled hydrogen experienced quicker alleviation of postoperative brain edema compared with participants in control (C) group that inhaled oxygen,, hydrogen/oxygen inhalation effectively reduced postoperative brain edema in glioma patients. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes.
Read MoreTwo weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study.
In 20 patients, after 2 weeks of hydrogen therapy, the number of exhausted and senescent cytotoxic T cells decreased to within the normal range, and there was an increase in killer Vδ1 cells.
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