Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water.
In rats, data showed that while MDA, TNF-α, IL-6, endocan, and endoglin, urea, and creatinine parameters increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read More[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].
In mice, compared with the sham operation and hydrogen control groups, in the sepsis group, the number of normal pyramidal neurons in the hippocampal CA1 region was markedly reduced, the apoptotic index was marked increased, the expressions of nucleus and total Nrf2 were partly increased, the activities of SOD and CAT in the hippocampus were significantly decreased. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.
In male Sprague-Dawley rats, sTZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of which were suppressed following treatment with hydrogen-rich saline. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreFructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas.
This preclinical study evaluated hydrogen gas in mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreNeuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
In the hippocampus, H₂ upregulated nuclear factor erythroid 2-related factor 2 (NRF2), attenuated nuclear factor kappa B (NF-κB) activation, reduced the BAX/BCL-2 ratio, preserved neuronal nuclei (NEUN) expression, and decreased hippocampal Aβ42 burden. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreNeuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning.
H2HUBB PLAIN-LANGUAGE TAKEAWAY The publication summarizes the rationale and available evidence for molecular hydrogen, but it does not by itself prove treatment effectiveness. Hydrogen-rich saline oxidative stress study 2013: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Neuroprotective effect of hydrogen-rich […]
Read MoreEffects of hydrogen water treatment on antioxidant system of litchi fruit during the pericarp browning.
Compared with control pericarp, the pericarp of HW-treated litchi fruit exhibited higher levels of superoxide radical (O₂-·) scavenging activity, glutathione (GSH), monodehydroascorbate reductase (MDHAR), polyphenol oxidase (PPO) and total flavonoids during whole storage, higher levels of hydrogen peroxide (H₂O₂), catalase (CAT), glutathione disulfide (GSSG), ascorbate oxidase (AAO) and total phenols only on day 1. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record. This plant postharvest study evaluated hydrogen water and is included as Related Mechanisms & Background Science. It provides no evidence of therapeutic effectiveness in humans or animals.
Read MoreHydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm.
HRW groups significantly reduced the expression of 8-OHdG induced by nickel exposure and inflammatory cytokine response including TNF-α. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.
In a laboratory model, a recent study demonstrated that hydrogen gas with a good permeability in biological membranes can treat various disorders by exerting its selective anti-oxidation and anti-inflammatory effects, indicating that hydrogen therapy plays a role in scavenging free radicals and in balancing oxidation and anti-oxidation systems of cells. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreHydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.
The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338-682 μg/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 × 107/mL along with the increase of correlative dissolved hydrogen. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreInhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.
In mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreA potential clinical application of hydrogen-rich saline in postoperative care.
H2HUBB PLAIN-LANGUAGE TAKEAWAY The publication summarizes the rationale and available evidence for molecular hydrogen, but it does not by itself prove treatment effectiveness. Hydrogen-rich saline research study 2023: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “A potential clinical application of […]
Read MoreHydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride.
This animal study examined Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride. The abstract describes Rat model; reported duration 4 weeks. The abstract reports: These results clarify the mechanism that CCH may exert antioxidant activity by significantly enhancing the basal endogenous antioxidant ability in the hippocampus through a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
This preclinical study evaluated molecular hydrogen in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreAntioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults.
Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
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