Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In mice, the present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity) and expression of mitochondrial biogenesis parameters (PGC-1α, NRF2, Tfam). These preclinical findings add evidence…
Read ArticleIn mice, molecular hydrogen is produced as a fermentation by-product in the large intestine of animals and its production can be correlated with the digestibility of the carbohydrates…
Read ArticleIn mice, the number of CD4(+) and CD8(+) cells as well as the ratio of CD4/CD8 increased to normal gradually, while the levels of TNF-α, IFN-γ, and IL-6…
Read ArticleIn mice, there are several mechanisms of how H₂ protects neuronal damage. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleThis in vitro or cellular study examined PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells. The…
Read ArticleIn female C57BL/6 mice, at the molecular level, HRW reduced spinal oxidative stress and ERK-dependent plasticity without altering spinal NLRP3 expression, whereas it fully reversed NLRP3 upregulation and…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. In the subsequent pathway, H₂ suppressed a free radical chain reaction, leading to decreases in lipid peroxide and its end…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Hydrogen gas, a promising neuroprotective agent, has been a focus of study due to its potent antioxidative properties. The reviewed…
Read ArticleIn an animal model, consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged…
Read ArticleIn pregnant mice fed a diet containing the Si-based agent, lipopolysaccharide (LPS)-induced miscarriage due to mother-to-child transmission was reduced and inflammation and neutrophil infiltration in the placenta were…
Read ArticleIn rats, H₂ significantly attenuated hydrogen peroxide-induced sFlt-1 expression, but could not reduce the expression induced by hypoxia in BeWo cells. These preclinical findings add evidence supporting molecular…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The present review evaluates the concept of 'hydrogen resuscitation', based on knowledge that hydrogen treatment effectively protects cells, tissues and…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. However, after chronic administration of H₂ in drinking water, oxidative-stress-induced nerve injury is significantly attenuated even in the absence of…
Read ArticleIn rats, concluded that HRW protects the neurons against lead-induced oxidative stress and has anti-apoptotic effects without a noticeable change in NO level which already was diminished by…
Read ArticleIn mice, plasma creatine kinase activities were decreased by hydrogen at ages 10 and 24 weeks. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
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