Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
This uncontrolled human study examined Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. The abstract describes Human participants. The abstract reports: We found that 2% H inhalation can reduce pro-inflammatory factors, alleviate DNMT1, DNMT3a but not DNMT3b expression, make hypomethylation of BDNF promoter IV at…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress.
This uncontrolled human study examined Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress. The abstract describes Human participants; reported duration 5 weeks. The abstract reports: Our results showed that H treatment improved the CIH-induced spatial learning and memory impairments. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress.
This animal study examined Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress. The abstract describes Rabbit model. The abstract reports: Results show that irrigation of the damaged eyes with H solution immediately after the injury and then within next five days renewed corneal transparency…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePreventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.
This narrative review examined Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals. The abstract describes Published literature review. The abstract reports: There is a growing body of evidence based on the results of animal experiments and clinical observations that H(2) may represent an effective antioxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
This randomized controlled trial examined Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. The abstract describes Human participants; sample size 73. The abstract reports: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway
This animal study examined Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway. The abstract describes Mouse model. The abstract reports: We found that H can improve survival in septic mice, decrease escape latency and platform crossing times, decrease pro-inflammatory cytokines and oxidative product levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review.
This narrative review examined Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review. The abstract describes Published literature review. The abstract reports: Therefore, we conducted a literature review on the mechanism by which H improves acute and chronic fatigue in animals and healthy people and showed…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.
This animal study examined Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation. The abstract describes Mouse model. The abstract reports: The protective effect of H on cognitive dysfunction induced by SAE may be achieved by inhibiting tau phosphorylation, which is perhaps related with the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRedox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.
This narrative review examined Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity. The abstract describes Published literature review. The abstract reports: Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats
This animal study examined A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. The abstract describes Rat model. The abstract reports: In this paper, we demonstrated that consumption of H-rich water (HRW) resulted in stimulated rat cardiac mitochondrial electron respiratory chain function and increased levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury.
This uncontrolled human study examined Protective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury. The abstract describes Human participants. The abstract reports: Ischemic injury is mainly caused by anaerobic cell death and reperfusion which results in a wide range of inflammatory responses. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension.
This animal study examined Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension. The abstract describes Rat model. The abstract reports: No differences in HR response to PE administration were found between any of the experimental groups. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition.
This in vitro or cellular study examined Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition. The abstract describes Endothelial cell model. The abstract reports: Our findings suggest that RhoA is a crucial protein in the signaling pathway of LPS-induced endothelial cell dysfunction. Hydrogen treatment can prevent LPS-induced junctional…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers.
This animal study examined Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers. The abstract describes Rat model. The abstract reports: The analysis results revealed distinct lipid metabolic alterations across cold storage, machine perfusion (MP), and hydrogen-supplemented perfusion (MP-H2) groups compared to healthy controls. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHigh-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.
This animal study examined High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. The abstract describes Mouse model; sample size 6. The abstract reports: HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. This is an automated editorial draft based on the abstract and requires source review before publication.
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