Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In rats, hydrogen-rich saline improved acidosis and renal function and reduced the release of inflammatory factors (TNF, IL-1β, and IL-6). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn rats, acute blue light exposure caused a decrease in ipRGC function, decreased expression of melanopsin protein and the melanopsin-positive RGCs, and diminished immunoreactivity in dendrites. These preclinical…
Read ArticleThe results using 60 min averages showed a statistically significant (p ≤ 0.007) decrease in oxygen saturation during molecular hydrogen inhalation (95.9 ± 1.0%) compared to placebo (96.7…
Read ArticleIn mice, consumption of H₂-water significantly attenuated APAP-induced liver injury, as evidenced by improved histological findings and decreased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. These…
Read ArticleIn 2 patients with sleep disorders, the control group showed no significant changes in sleep parameters during treatment, whereas the hydrogen-oxygen group showed significant improvements in total sleep…
Read ArticleIn a laboratory model, H₂ suppressed the expression of HIF1α and PDK1, suggesting that H₂ may act upstream of hypoxia-driven signaling pathways. The authors concluded that the findings…
Read ArticleIn cancer cells, the asymmetric PAA-AB@PDA NPs selectively scavenge cytotoxic ·OH, thereby disrupting the redox homeostasis, which in turn leads to mitochondrial damage and reduced ATP production. These…
Read ArticleThis meta analysis examined this study aimed to systematically evaluate the preclinical evidence on the therapeutic efficacy and underlying mechanisms of hydrogen-delivering biomaterial carriers in the treatment of…
Read ArticleIn mice, H₂ pretreatment by intraperitoneal injection improved LPS-induced acute liver injury in mice as indicated by reducing inflammatory cells infiltration in the liver, down-regulating serum ALT and…
Read ArticleIn Sprague-Dawley rats, hRS reduced MNU-induced cataract incidence to 50% versus 100% in MNU-only and NS groups and preserved lens clarity comparable to normal controls. These preclinical findings…
Read ArticleThis narrative review examined recent progress in molecular H₂ research, spanning from fundamental mechanisms in cancer biology, the role in adjuvant therapy, to the development of innovative catalytic…
Read ArticleIn a rat model of MIR injury, intravenous injection of H₂-MBs followed by ultrasound-targeted microbubble destruction (UTMD) significantly improved cardiac function (ejection fraction and fractional shortening), reduced infarct…
Read ArticleIn mice, rOS fluorescence staining and flow cytometry showed that HNBs significantly reduced Dox-induced ROS increases. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleThis narrative review examined nevertheless, this narrative review provides a novel theoretical framework integrating hydrogen with the mast cell‐sleep‐wake rhythm‐melatonin axis, identifies shared pathological targets (oxidative stress, mitochondrial…
Read ArticleIn mice, western blot analysis showed hydrogen treatment reduced the contents of apolipoprotein B (apoB), a major protein constituent of non-HDL in either plasma or hepatic tissues. These…
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