Decompression comparison of helium and hydrogen in rats.
In this animal study, the authors report that H2 potency for causing decompression sickness was found to be up to 35% greater than that for He.
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HydroMg attenuates doxorubicin-induced myocardial injury via promoting mitochondrial function.
In this animal study, the authors report that In vitro studies showed that 1 μg/mL HydroMg treatment attenuated doxorubicin-induced cardiomyocyte death by inhibiting apoptosis, reducing reactive oxygen species…
Read ArticleHydrogen micro-nano bubbles mitigate polystyrene microplastics-induced toxicity through gut microbiota composition and metabolic functions
In this animal study, the authors report that Using a Caco-2 cell exposure model, we assessed viability, apoptosis, and LDH release.
Read ArticleInfluence of alkaline ionized water on rat erythrocyte hexokinase activity and myocardium
In rats, body weight of male and female rats given AKWA at 3 to 11 weeks of age after birth significantly increased beyond control group values. These preclinical…
Read ArticleAnti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice
Long-term administration of “active hydrogen water” generated using magnesium was associated with improved blood-glucose control and higher antioxidant/SOD-like activity in KK-Ay diabetic mice, while normal mice did not…
Read ArticleHydrogen-containing saline attenuates doxorubicin-induced heart failure in rats
The researchers found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing…
Read ArticleEffects of hydrogen water on paraquat-induced pulmonary fibrosis in mice
In male C57BL/6 mice, although no significant difference was observed in compliance, it tended to be higher in the PQ + HW group. These preclinical findings add evidence…
Read ArticleAnti-diabetic effect of alkaline-reduced water on OLETF rats
In rats, alkalin-reduced water (ARW) is known to exert several anti-cancer effects, as well as to scavenge reactive oxygen species (ROS) and reduce blood-glucose levels. These preclinical findings…
Read ArticleHydrogen activated the Nrf2/HO pathway to alleviate the cognitive decline in PD Drosophila after long-term sevoflurane exposure
In an animal model, pD flies with H₂ inhalation after sevoflurane exposure showed increased nuclear levels of Nrf2 and expression of its downstream target HO. These preclinical findings…
Read ArticleHydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock—A Proof-of-Concept Study
In an animal model, increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine. These preclinical findings add evidence about the molecular-hydrogen effects,…
Read ArticleA hydrogen-releasing polydopamine palladium hydride nanocoating protects airway mucosal injury induced by endotracheal tube cuff compression
In an animal model, the coating significantly reduced malondialdehyde and nitric oxide levels, enhanced superoxide dismutase activity, and protected mitochondrial integrity and cytoskeletal structure. These preclinical findings add…
Read ArticleEfficacy of silicon-based agent against aging-related frailty
In aged C57BL/6J mice, the Si-based agent mitigated oxidative stress, suppressed motor performance and body weight decline, and reduced early mortality associated with age-related deterioration. These preclinical findings…
Read ArticlePreservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair
In an animal model, here, the researchers show that the viability and hyaline cartilage phenotype of bone marrow-derived mesenchymal stem cell (BMSC)-derived chondrocyte microspheroids (CMSs) can be efficiently…
Read ArticlePerioperative Mitigation of Oxidative Stress with Molecular Hydrogen During Simulated Heart Transplantation in Pigs
In a simulated pig heart-transplantation model, 2% molecular hydrogen during anesthesia and extracorporeal circulation was associated with lower selected injury, lipid-peroxidation, and inflammatory markers and with improved functional…
Read Articleability with high mortality. Hydrogen-rich saline, which has therapeutic anti-inflammatory and anti-apoptotic activity, can attenuate pulmonary edema in sepsis-related lung injury. However, the mechanisms of the protective effect are
In male Sprague-Dawley rats, pretreatment with hydrogen-rich saline significantly alleviated pulmonary edema and attenuated the deterioration of claudin-5 protein induced by LPS in rat lung. These preclinical findings…
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