H 2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model
This animal study examined H 2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model. The abstract describes Rat model. The abstract reports: Inhalation of H(2) gas is a favorable strategy to mitigate mortality and functional outcome of post-CA syndrome in a rat model, either alone or…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage.
This animal study examined Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage. The abstract describes Rat model; sample size 36. The abstract reports: Subarachnoid hemorrhage (SAH) results in high rates of mortality and lasting disability. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreGender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.
This uncontrolled human study examined Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression. The abstract describes Human participants; reported duration 3 days. The abstract reports: Estrogen was responsible for increased H sensitivity in male mice with ICH. The underlying mechanism may be associated with the suppression of NF-κB signaling…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.
This study protocol examined Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. The abstract describes Planned or registered research population; sample size 450; hydrogen delivered as injected or infused hydrogen. The abstract reports: Recent accumulating evidence has suggested that early brain injury is also involved in the development of delayed cerebral ischemia, and that hydrogen can prevent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen exerts neuroprotection by activation of the miR‐21/PI3K/AKT/GSK‐3β pathway in an in vitro model of traumatic brain injury
This in vitro or cellular study examined Hydrogen exerts neuroprotection by activation of the miR‐21/PI3K/AKT/GSK‐3β pathway in an in vitro model of traumatic brain injury. The abstract describes PC12 cell model. The abstract reports: The results showed that hydrogen-rich medium improved neurite regeneration and inhibited apoptosis in the injured cells. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEarly Hydrogen–Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial
This study protocol examined Early Hydrogen–Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial. The abstract describes Planned or registered research population; hydrogen delivered as oxyhydrogen. The abstract reports: All results of the present study will be published in peer-reviewed journals and presented at relevant conferences. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway.
This animal study examined Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEfficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial
This registered clinical trial examined Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. The abstract describes Planned or registered research population; sample size 429; hydrogen delivered as hydrogen inhalation. The abstract reports: The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway.
This uncontrolled human study examined Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest
This animal study examined Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest. The abstract describes Rat model. The abstract reports: The results showed that H therapy significantly improved post-resuscitation survival and cardiac function. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis.
This uncontrolled human study examined Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: H improves TBI-ALI, and the mechanism may be due to the decrease of both pyroptosis and apoptosis and the alleviation of inflammation. These findings…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreIntravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage
This randomized controlled trial examined Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen; reported duration 14 days. The abstract reports: Intracisternal magnesium sulfate infusion started immediately after surgery reduces the incidence of cerebral vasospasm and delayed cerebral ischemia and improves clinical outcomes without complications…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury
This animal study examined Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Recent studies have demonstrated the potential neuroprotective effects of molecular hydrogen on TBI. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats.
This uncontrolled human study examined Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats. The abstract describes Human participants. The abstract reports: We found that the inhalation of high concentrations of H significantly improved outcomes following TBI in diabetic rats. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest
This animal study examined Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation; reported duration 1 hour. The abstract reports: Our findings suggest that water electrolysis derived 67% hydrogen gas may be an effective therapeutic approach for improving cognitive outcomes associated with global brain…. This is an automated editorial draft based on the abstract and requires source review before publication.
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