A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

This uncontrolled human study examined A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. The abstract describes Human participants; sample size 10; reported duration 30 min. The abstract reports: H2 inhalation of at least 3% concentration for 30 min delivered enough HC, equivalent to the animal experiment levels, in the blood without compromising…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies.

This uncontrolled human study examined Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Data from the current study indicate that an H2-enriched intravenous solution is safe for patients with acute cerebral infarction, including patients treated with t-PA. This is an automated editorial draft based on the abstract and requires source review before publication.

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Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.

This uncontrolled human study examined Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of 2.4% hydrogen gas does not appear to cause clinically significant adverse effects in healthy adults. Although these data suggest that inhaled hydrogen…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

This randomized controlled trial examined Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. The abstract describes Human participants; sample size 50; hydrogen delivered as hydrogen inhalation. The abstract reports: H treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients.

This observational study examined Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients. The abstract describes Human participants; sample size 10; hydrogen delivered as hydrogen inhalation. The abstract reports: H gas inhalation combined with CCRT is feasible and safe for patients with LAHNC. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

This uncontrolled human study examined Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study. The abstract describes Human participants; sample size 1088; hydrogen delivered as hydrogen inhalation; reported duration 6 month. The abstract reports: HI as an adjunct therapy ameliorates glycemic control, lipid metabolism, insulin resistance and AE incidence of T2DM patients after 6-month treatment, presenting a noteworthy…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.

This case report or case series examined Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study. The abstract describes Human participants. The abstract reports: This study is the first human clinical trial evaluating HRCC capsules in patients with metabolic syndrome. Based on the safety and potential TG-lowering effects…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study.

This observational study examined Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: HI therapy significantly improves glycemic control, weight, insulin dose, lipid metabolism, β-cell function and insulin resistance of patients with type 2 diabetes after 6…. This is an automated editorial draft based on the abstract and requires source review before publication.

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The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial.

This randomized controlled trial examined The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial. The abstract describes Human participants; sample size 60; hydrogen delivered as oxyhydrogen. The abstract reports: When stratified by age (aged 50-59 years aged 60-70 years), participants in the older H-O group showed a larger reduction in right arm SBP compared with…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial

This registered clinical trial examined Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial. The abstract describes Planned or registered research population. The abstract reports: The trial demonstrated that hydrogen/oxygen therapy is superior to oxygen therapy in patient with AECOPD with acceptable safety and tolerability profile. This is an automated editorial draft based on the abstract and requires source review before publication.

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Preliminary Effects of Hydrogen-Oxygen Inhalation on Nodule Size, IL-6, and Neutrophils in Patients with Small Pulmonary Nodules

This registered clinical trial examined Preliminary Effects of Hydrogen-Oxygen Inhalation on Nodule Size, IL-6, and Neutrophils in Patients with Small Pulmonary Nodules. The abstract describes Planned or registered research population; sample size 30; hydrogen delivered as oxyhydrogen; reported duration 3 month. The abstract reports: Within the limitations of this single-center, small-sample study with a 3-month follow-up, hydrogen-oxygen inhalation can reduce SPN diameter and downregulate peripheral blood IL-6 and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.

This observational study examined Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. The abstract describes Human participants; sample size 10; hydrogen delivered as hydrogen inhalation; reported duration 45 min. The abstract reports: A single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD. This is an automated editorial draft based on the abstract and requires source review before publication.

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Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study.

This uncontrolled human study examined Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: Treatment with HRW in patients with hypoxia from chronic lung diseases may decrease oxidative stress and improve oxygen saturation in some patients. HRW therapy…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study

This randomized controlled trial examined Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: This pilot study revealed that the inhalation of molecular hydrogen gas was safe, but did not show any beneficial effects in patients with PD. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial

This randomized controlled trial examined Pilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial. The abstract describes Human participants; sample size 9; reported duration 48 weeks. The abstract reports: The results indicated that drinking H₂-water was safe and well tolerated, and a significant improvement in total UPDRS scores for patients in the H₂-water…. This is an automated editorial draft based on the abstract and requires source review before publication.

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