Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In rats, however, after treatment with HSS, all of these changes were alleviated (P < 0.05), and these changes were mitigated when treated with HSS by ip then iv injection (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn male Sprague-Dawley rats, hydrogen water consumption reduced wet-to-dry weight ratio, malondialdehyde and myeloperoxidase activity and decreased the concentration of TNF-α, IL-1β, and IL-6 in the lung tissues…
Read ArticleIn a laboratory model, western blot analysis showed that hydrogen significantly upregulated the levels of phosphorylated AMPK (p-AMPK) and lowered the LPS-induced increased expression of dynamin-related protein 1…
Read ArticleUpon administration of H₂, the inflammatory infiltration degree of the LPS-induced placenta was reduced, and infiltration significantly narrowed. This source-grounded publication contributes evidence relevant to molecular hydrogen and…
Read ArticleIn rats, hydrogen-rich saline (LH group) treatment significantly decreased the p38 MAPK mRNA expression and p-p38 MAPK protein levels compared with the L group (p < 0.05). These…
Read ArticleIn Sprague-Dawley rats, hydrogen-rich saline treatment decreased the blood and placental MDA, proteinuria and the pro-inflammatory cytokine TNF-α, IL-1β in the placental tissues compared with those in L-NAME-treated…
Read ArticleIn rats, eLISA analysis showed decreased TNF-α and IL-1β and increased IL-10 expression levels in the hydrogen-rich saline-treated group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn an animal model, hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial…
Read ArticleIn rats, pretreatment with H₂ inhalation significantly attenuated seizure intensity; prevented neuronal loss; decreased microglial and astrocytic activation; decreased ROS, TNF-α, IL-1β, IL-6, CCL2 and CCL3 levels; and…
Read ArticleIn an animal model, cUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich…
Read ArticleIn rats, inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines,…
Read ArticleIn mice, the anti-pyroptosis effects of H₂ in vitro were further confirmed by the reduced expression of inflammatory cytokines, the decreased full-length and cleaved forms of GSDMD and…
Read ArticleIn mice, intraperitoneal injection of H₂ improved acute ethanol-induced liver injury in mice in a dose dependent manner, as indicated by decreasing serum ALT and AST levels, hepatic…
Read ArticleIn mice, crystal deposition, tubular injury, fibrosis and increased ROS production in kidneys of mice induced by oxalate diet were improved with HRW administration. These preclinical findings add…
Read ArticleIn Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions, meanwhile, ROS also serve as signaling mediators to upregulate…
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