Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
This animal study examined Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species. The abstract describes Mouse model. The abstract reports: Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreOpen-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.
Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging activities that eliminate hydroxyl radical and peroxynitrite, and also to signal-modulating activities, but the detailed molecular mechanisms still remain elusive.
Read MoreMorphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed mycotoxins contaminated diet.
This animal study examined Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed mycotoxins contaminated diet. The abstract describes Porcine model; hydrogen delivered as hydrogen water. The abstract reports: It is well known that mycotoxins will lead a breakdown of the normally impeccable epithelial barrier, resulting in the development of a "leaky" gut. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDrinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats.
This uncontrolled human study examined Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Lack of dose responses of hydrogen and the presence of favorable effects with hydrogen water and intermittent hydrogen gas suggest that signal modulating activities…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydration bioanalyses of the effects of hydrogen-rich water (HRW).
This uncontrolled human study examined Hydration bioanalyses of the effects of hydrogen-rich water (HRW). The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Conclusions: These results suggest that measurable hydration effects in the human body may be achieved through regular intake of HEW. The findings of the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates.
Read MoreEffects of Long-Term Hydrogen Intervention on Plasma Metabolites and Gut Microbiome of Rats in Health Status
This animal study examined Effects of Long-Term Hydrogen Intervention on Plasma Metabolites and Gut Microbiome of Rats in Health Status. The abstract describes Rat model; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players.
This randomized controlled trial examined Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 3 weeks. The abstract reports: Two-way (supplementation and time) repeated-measures analyses of variance showed that NO, L-arginine, and tetrahydrobiopterin levels in the H inhalation group were significantly higher than…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreModulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision.
This uncontrolled human study examined Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision. The abstract describes Human participants; reported duration 3 months. The abstract reports: Overall results demonstrated that an optimal oxidative balance can be restored and GERD symptoms can be reduced rapidly via the integration of ERW in…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA systematic literature review of the effects of molecular hydrogen during exercise
In the last decade, use of molecular hydrogen, through hydrogen-rich water (HRW), has become commonplace in the sports industry with anecdotal claims of improving athletic performance and endurance. Publications, clinical trials, and case studies have begun to emerge with the growing interest to clinically-validate the claims of improved performance and recovery in the athletic population. The objective of the current article is to review the recent literature to understand the effects of molecular hydrogen, through ingestion of hydrogen-rich water on muscles, joints, and athletic performance during the peri-exercise period.
Read MoreHydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase.
This uncontrolled human study examined Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase. The abstract describes Human participants. The abstract reports: We found that hydrogen-rich medium could inhibit adhesion of monocytes to endothelial cells and decrease levels of adhesion molecules, whereas the levels of transepithelial/endothelial…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways.
This animal study examined Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways. The abstract describes Animal model; hydrogen delivered as injected or infused hydrogen; reported duration 6 weeks. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy.
This animal study examined Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy. The abstract describes Rat model; reported duration 1 hour. The abstract reports: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.
This in vitro or cellular study examined Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin. The abstract describes HUVEC model. The abstract reports: Fluorescence results showed that, compared with control cells, the VE-cadherin in LPS cells was in-complete at the cell joints. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEarly Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats.
This animal study examined Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. This is an automated editorial draft based on the abstract and requires source review before publication.
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