Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment
This in vitro or cellular study examined Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment. The abstract describes Fibroblast model; hydrogen delivered as hydrogen water. The abstract reports: Extract from HW-treated HGF cells scavenged ROO· more markedly than that from DDW-treated cells, suggesting that HW can increase the intracellular antioxidant capacity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice.
This animal study examined Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice. The abstract describes Mouse model; sample size 11; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: Levels of serum thymus and activation-regulated chemokine (TARC) and cytokines in the AD lesion were measured by ELISA; and mRNA expression of TARC and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level
This uncontrolled human study examined A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. The abstract describes Human participants; sample size 10; reported duration 30 min. The abstract reports: H2 inhalation of at least 3% concentration for 30 min delivered enough HC, equivalent to the animal experiment levels, in the blood without compromising…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA Systematic Review of Molecular Hydrogen Therapy in Cancer Management.
Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H2 therapy on cancer management.
Read MoreHydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.
This animal study examined Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 12 weeks. The abstract reports: ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA narrative review of hydrogen therapy for COPD: aging-related insights.
Molecular hydrogen (H) exhibits selective antioxidant, anti-inflammatory, and anti-senescence properties that may provide therapeutic benefits for chronic obstructive pulmonary disease (COPD), particularly in aging populations where oxidative stress and chronic inflammation are prominent. Given the increasing burden of aging-related COPD and the emerging biological effects of molecular hydrogen, we hypothesized that H therapy may exert beneficial effects by modulating oxidative stress, inflammation, and aging pathways. Following Ferrari's narrative review framework, PubMed and Ovid MEDLINE were searched through October 2025 for clinical and preclinical studies examining H interventions in COPD, chronic…
Read MoreMaternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.
This animal study examined Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. The abstract describes Rat model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAttenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats.
This animal study examined Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Hydrogen-rich saline pretreatment ameliorated CS-induced airway mucus production and airway epithelium damage in rats. The protective role of hydrogen on CS-exposed rat lungs was…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
This animal study examined Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: This study suggests that hydrogen-rich saline could partially protect spermatogenesis and hematopoiesis in irradiated mice. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3
This animal study examined Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3. The abstract describes Mouse model; sample size 10; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals.
This animal study examined Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.
Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated.
Read MoreElectrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water
This in vitro or cellular study examined Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. The abstract describes HT1080 cell model. The abstract reports: ERW has reactive oxygen species (ROS)-scavenging activity and recent studies demonstrated that hydrogen-dissolved water exhibits ROS-scavenging activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles
This meta-analysis examined Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles. The abstract describes Published literature review; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen is neuroprotective against surgically induced brain injury.
This uncontrolled human study examined Hydrogen is neuroprotective against surgically induced brain injury. The abstract describes Human participants. The abstract reports: SBI resulted in localized brain edema (p = < 0.001). This is an automated editorial draft based on the abstract and requires source review before publication.
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